ls

LS-102 is a selective inhibitor of the E3 ligase synoviolin (Syvn1), an astragaloside IV derivative, which attenuates myocardial ischemia/reperfusion injury by inhibiting mitochondrial fission.LS-102 inhibits Syvn1 auto-ubiquitylation, which ameliorates amyloidazole-induced slowing of the heart rate, and is useful for studying cardiovascular diseases.

LS2265, a fenofibrate derivative with a taurine modification, effectively induces the proliferation of peroxisomes in rat liver cells.

LS-104 is a JAK2 inhibitor.

LS 80707 is a herbicide.

LS 82-556 is a peroxidizing herbicide.

LS-58500 is a bioacive chemical.

Pirenzepine dihydrochloride (LS519) is a selective M1 muscarinic receptor antagonist, inhibiting gastric secretion.

Sodium lauroyl glutamate (Acylglutamate LS-11) is an amino acid detergent and increases the solubility of long-chain alkyl gallates such as alkyl gallates.

Glabridin (KB-289522) may serve as an anti-inflammatory agent in diabetes-related vascular dysfunction, through regulating the synthesis and activity of iNOS under high-glucose levels; may possess a therapeutic effect on metabolic disorders( such as diabetes and hyperglycemia), by modulating glucose metabolism through AMPK in skeletal muscle cells. Glabridin may have potential as a chemopreventive agent against liver Y metastasis, by inhibiting the invasion of human HCC cells.

Ketorolac tromethamine salt (Ketorolac tris salt) non-selective inhibits the enzymes cyclooxygenase 1 (COX-1) and COX-2with anti-inflammatory, analgesic, and antipyretic activities.

CDKI-73 is a potent CDK9 inhibitor (Ki: 4 nM). It shows selective toxicity to CLL cells(LD50=80 nM) versus normal B cell and normal CD34+ cell(LD50>20 uM).The inhibition of CDK9 induces apoptosis and potentiates the effect of cisplatin.

Lotilaner is a parasiticide. It is used as a potent non-competitive antagonist of insects GABACl receptors (IC50 of 23.84 nM for Drosophila melanogaster GABA receptor). It also has no effect on a dog GABAA receptor.

NS-220, a selective agonist of peroxisome proliferator-activated receptor alpha, potently decreases plasma triglyceride and glucose levels and modifies lipoprotein profiles in KK-Ay mice.

GYKI-13380, also known as LS-79445, is a small molecule with potent bioactivity. Detail information has not been published yet.

Roquinimex (FCF89) (Linomide) is a quinoline derivative immunostimulant which increases NK cell activity and macrophage cytotoxicity; inhibits angiogenesis and reduces the secretion of TNF alpha.

Estramustine phosphate can be used to treat prostatic neoplasms; also has radiation protective properties.

L-Alloisoleucine (L-allo-Isoleucine) is a branched chain amino acid and is a stereoisomer of L-isoleucine. It is a common constituent of human plasma (albeit at low levels). L-alloisoleucine is produced as a byproduct of isoleucine transamination. Plasma L-alloisoleucine, which is derived from L-isoleucine in vivo, can be used for the diagnosis of maple syrup urine disease (MSUD), a genetic disorder. Indeed, plasma L-alloisoleucine levels above 5 μmol/L is the most specific and most sensitive diagnostic marker for all forms of MSUD.

(E/Z)-Ensifentrine is a potent and selective PDE3/4 inhibitor that acts as a long-acting inhibitor of the phosphodiesterase enzymes PDE-3 and PDE-4, producing both bronchodilator and anti-inflammatory effects. It is being developed by Verona Pharma as a potential treatment for asthma and hay fever and is currently in clinical trials.

Crexavibart (BMS-986413; C-144-LS), an IgG1 λ2 antibody, specifically targets the receptor-binding domain of the SARS-CoV-2 spike (S) glycoprotein [1].

LS-BF1, a stable and low-toxicity cationic antimicrobial peptide, exhibits broad-spectrum antibacterial activity that encompasses the notorious ESKAPE pathogens through a cell membrane disruption mechanism. The compound demonstrates effective in vivo bacterial elimination in a mouse infection model[1].

LSTc (LS-tetrasaccharide c), a human lactooligosaccharide found on glycoproteins and glycolipids, serves as a specific recognition motif for the human JC polyomavirus (JCV). This compound holds considerable potential for research into progressive multifocal leukoencephalopathy (PML) [1].

FK-330 (FR-260330) is a novel orally active inducible nitric oxide synthase inhibitor with potential anticancer and antitumor activity that prevents ischemia and reperfusion injury in rat liver transplantation.

SU-8000 is an inhibitor of 17α-hydroxylase/17,20-lyase (P450 17α).

Glycidamide is a carcinogen and metabolite of acrylamide that induces DNA adduct formation and mutations.