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Deoxyandrographolide

Name: Deoxyandrographolide
Brand: TargetMol
SKU: TQ0218
Price: 395 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TQ0218Cas No. 79233-15-1

Alias 14-deoxyandrographolide

Deoxyandrographolide (14-deoxyandrographolide) potentiates NGF-induced neurite outgrowth. Deoxyandrographolide suppresses the production of proinflammatory mediators TNF-α and IL-6.

Deoxyandrographolide

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Purity: 98.98%

Catalog No. TQ0218Alias 14-deoxyandrographolideCas No. 79233-15-1

Deoxyandrographolide (14-deoxyandrographolide) potentiates NGF-induced neurite outgrowth. Deoxyandrographolide suppresses the production of proinflammatory mediators TNF-α and IL-6.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$73	-	In Stock
2 mg	$105	-	In Stock
5 mg	$166	-	In Stock
10 mg	$247	-	In Stock
25 mg	$395	-	In Stock
50 mg	Preferential	-	In Stock
1 mL x 10 mM (in DMSO)	$175	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:98.98%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Deoxyandrographolide (14-deoxyandrographolide) potentiates NGF-induced neurite outgrowth. Deoxyandrographolide suppresses the production of proinflammatory mediators TNF-α and IL-6.
In vitro	Treatment with 14-deoxyandrographolide (14-DAG) activated AMPK through induction of cyclic AMP-protein kinase A pathway [1]. 14-DAG down-regulated the formation of a death-inducing signaling complex, resulting in the desensitization of hepatocytes to TNF-alpha-induced apoptosis. Pretreatment of hepatocytes with 14-DAG accentuated microsomal Ca-ATPase activity through induction of NO/cGMP pathway [2]. 14-DAG, in concentrations between 10-100 μM, reduced the extracellular acidification rate and the intracellular alkalinization in a dose-dependent manner. In addition, 14-DAG reduced PAF-induced calcium flux in the presence of extracellular calcium, and tyrosine phosphorylation of a 44 kDa protein corresponding to the MAPK(ERK1) [3].
In vivo	The protective effect of 14-DAG against ethanol-induced hepatic injury is based on its ability to reduce oxidative stress through cNOS dependent improvement of redox status. 14-DAG mediated activation of adenylate cyclase-cAMP signaling leading to the up-regulation of cNOS may provide a promising approach in the prevention of liver diseases during chronic alcoholism [4].
Synonyms	14-deoxyandrographolide

Chemical Properties

Molecular Weight	334.45
Formula	C₂₀H₃₀O₄
Cas No.	79233-15-1
Smiles	[H][C@]12CCC(C)=C(CCC3=CCOC3=O)[C@]1(C)CC[C@@H](O)[C@@]2(C)CO
Relative Density.	1.123 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 10 mg/mL (29.9 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (2.99 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9900 mL	14.9499 mL	29.8998 mL	149.4992 mL
5 mM	0.5980 mL	2.9900 mL	5.9800 mL	29.8998 mL
10 mM	0.2990 mL	1.4950 mL	2.9900 mL	14.9499 mL
20 mM	0.1495 mL	0.7475 mL	1.4950 mL	7.4750 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

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