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Sacubitril sodium

Name: Sacubitril sodium
Brand: TargetMol
SKU: T4574L
Price: 37 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T4574LCas No. 149690-05-1

Alias LCZ696, LCZ 696, AHU377, AHU 377

Sacubitril sodium (AHU-377) is a potent NEP inhibitor with an IC50=5 nM for the treatment of heart failure or in combination with antihypertensive agents.

Sacubitril sodium

🥰Excellent

Purity: 99.97%

Catalog No. T4574LAlias LCZ696, LCZ 696, AHU377, AHU 377Cas No. 149690-05-1

Sacubitril sodium (AHU-377) is a potent NEP inhibitor with an IC50=5 nM for the treatment of heart failure or in combination with antihypertensive agents.

Pack Size	Price	Availability
2 mg	$37	In Stock
5 mg	$59	In Stock
10 mg	$81	In Stock
25 mg	$117	In Stock
50 mg	$155	In Stock
100 mg	$248	In Stock
200 mg	$373	In Stock
1 mL x 10 mM (in DMSO)	$65	In Stock

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Purity:99.97%

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COA LCMS HNMR

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Product Introduction

Bioactivity

Description	Sacubitril sodium (AHU-377) is a potent NEP inhibitor with an IC50=5 nM for the treatment of heart failure or in combination with antihypertensive agents.
In vivo	In volume-dependent hypertensive rat models, oral administration of Sacubitril sodium (30 and 100 mg/kg) produced a dose-dependent antihypertensive effect in Dahl salt-sensitive (Dahl-SS) rats. In contrast, only modest blood pressure reduction was observed in DOCA-salt rats, despite achieving >95% neprilysin enzyme occupancy at 100 mg/kg, indicating greater sensitivity to neprilysin inhibition in the Dahl-SS model[2].
Alias	LCZ696, LCZ 696, AHU377, AHU 377

Chemical Properties

Molecular Weight	433.47
Formula	C₂₄H₂₈NNaO₅
Cas No.	149690-05-1
Smiles	CCOC([C@H](C)C[C@H](NC(CCC([O-])=O)=O)CC1=CC=C(C2=CC=CC=C2)C=C1)=O.[Na+]
Relative Density.	no data available

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

H2O: < 1 mg/mL (insoluble)

DMSO: 10 mg/mL (23.07 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3070 mL	11.5348 mL	23.0696 mL	115.3482 mL
5 mM	0.4614 mL	2.3070 mL	4.6139 mL	23.0696 mL
10 mM	0.2307 mL	1.1535 mL	2.3070 mL	11.5348 mL
20 mM	0.1153 mL	0.5767 mL	1.1535 mL	5.7674 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

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