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NSC 3852

Name: NSC 3852
Brand: TargetMol
SKU: T7691
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T7691Cas No. 3565-26-2

NSC 3852 is a potent inhibitor of histone deacetylase.

NSC 3852

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Purity: 99.64%

Catalog No. T7691Cas No. 3565-26-2

NSC 3852 is a potent inhibitor of histone deacetylase.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
200 mg	$29	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.64%

Appearance:Solid

Color:Yellow

Resource Download

COA HNMR LCMS

Product Introduction

NSC 3852 AI Summary

NSC 3852 exhibits a diverse range of bioactivities, demonstrating significant potential in both antiviral and anticancer applications. It is potent in assays related to epigenetic regulation, miRNA modulation, promoter activation, and enzyme inhibition, including the inhibition of proteins like JMJD2E, JMJD2A-Tudor Domain, TDP1, aldehyde dehydrogenase 1, and fructose-1,6-bisphosphate aldolase, often with potency in the nanomolar range. Additionally, it shows cytotoxic effects on specific cell lines and inhibits transcriptional activities, contributing to growth inhibition in various human tumor cell lines. In the context of antiviral activity, NSC 3852 inhibits SARS-CoV-2 induced cytotoxicity in Caco-2 and VERO-6 cells at a concentration of 10 µM after 48 hours, with inhibition percentages of -25.75% and 0.41%, respectively. It also inhibits the SARS-CoV-2 3CL-Pro protease at 20 µM with an inhibition rate of 20.69%. Moreover, NSC 3852 demonstrates potential as an inhibitor of human HDAC6, showing an inhibition rate of -22.91% with a commercial peptide substrate and 3.05% with a custom peptide substrate, reflecting variability based on substrate specificity. These findings underscore its potential as a multi-faceted therapeutic agent..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

NSC 3852 is a potent inhibitor of histone deacetylase.

Chemical Properties

Molecular Weight	174.16
Formula	C₉H₆N₂O₂
Cas No.	3565-26-2
Smiles	OC1=C2N=CC=CC2=C(C=C1)N=O
Relative Density.	1.4g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 6.88 mg/mL (39.5 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	5.7418 mL	28.7092 mL	57.4185 mL	287.0923 mL
5 mM	1.1484 mL	5.7418 mL	11.4837 mL	57.4185 mL
10 mM	0.5742 mL	2.8709 mL	5.7418 mL	28.7092 mL
20 mM	0.2871 mL	1.4355 mL	2.8709 mL	14.3546 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc