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Perforin-IN-3
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Catalog No. T218726 Copy Product Info
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Perforin-IN-3 is a specific perforin inhibitor that prevents perforin-mediated pore formation in cell membranes and subsequent cell lysis. It effectively inhibits the cytotoxic effects of NK cells on target cells such as leukemia without interfering with FasL- or TRAIL-mediated cell death pathways. Perforin-IN-3 does not affect pneumolysin and can be utilized for studying autoimmune diseases, allograft rejection, graft-versus-host disease, and familial hemophagocytic lymphohistiocytosis [FHL].
Perforin-IN-3
Cas No. 178970-88-2
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | 10-14 weeks | 10-14 weeks | |
| 50 mg | Inquiry | 10-14 weeks | 10-14 weeks |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Perforin-IN-3 is a specific perforin inhibitor that prevents perforin-mediated pore formation in cell membranes and subsequent cell lysis. It effectively inhibits the cytotoxic effects of NK cells on target cells such as leukemia without interfering with FasL- or TRAIL-mediated cell death pathways. Perforin-IN-3 does not affect pneumolysin and can be utilized for studying autoimmune diseases, allograft rejection, graft-versus-host disease, and familial hemophagocytic lymphohistiocytosis [FHL]. |
| In vitro | Perforin-IN-3 (compound 1) inhibits perforin-mediated lysis of Jurkat T lymphoma cells with an IC 50 (4 h) of 2.7 μM. It reduces the KHYG-1 NK cell-mediated killing rate of K562 leukemia target cells by 50%, and after a 24-hour exposure, the survival rate of KHYG-1 NK cells remains at 72%. At a concentration of 20 μM for 30 minutes, Perforin-IN-3 does not inhibit Fas ligand or TRAIL-mediated death of Jurkat T lymphoma cells. Additionally, it suppresses primary human NK cell-mediated lysis of K562 leukemia target cells by more than 70%. |
| Molecular Weight | 273.31 |
| Formula | C14H11NO3S |
| Cas No. | 178970-88-2 |
| Smiles | C(=C\1/C2=C(C(=O)O1)C(=S)NC(C)=C2)\C3=CC=C(C)O3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: Perforin-IN-3 in vitro | Perforin-IN-3 formula | Perforin-IN-3 molecular weight
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