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Tetraacetylphytosphingosine
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Catalog No. T88593Cas No. 13018-48-9
Tetraacetylphytosphingosine is a sphingolipid metabolite produced through the acetylation of plant sphingosine. It functions as an angiogenesis inhibitor by suppressing the activation of MAPK and increasing intracellular calcium ions. Additionally, Tetraacetylphytosphingosine induces apoptosis in HaCaT cells.
Tetraacetylphytosphingosine
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Catalog No. T88593Cas No. 13018-48-9
Tetraacetylphytosphingosine is a sphingolipid metabolite produced through the acetylation of plant sphingosine. It functions as an angiogenesis inhibitor by suppressing the activation of MAPK and increasing intracellular calcium ions. Additionally, Tetraacetylphytosphingosine induces apoptosis in HaCaT cells.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | 10-14 weeks | 10-14 weeks | |
| 50 mg | Inquiry | 10-14 weeks | 10-14 weeks |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Storage & Solubility Information
| Description | Tetraacetylphytosphingosine is a sphingolipid metabolite produced through the acetylation of plant sphingosine. It functions as an angiogenesis inhibitor by suppressing the activation of MAPK and increasing intracellular calcium ions. Additionally, Tetraacetylphytosphingosine induces apoptosis in HaCaT cells. |
| In vitro | Tetraacetylphytosphingosine (TAPS; 5 μM; 24 hours) significantly reduces chemotactic migration and capillary-like tube formation induced by VEGF in HUVEC cells. It inhibits the production of proteolytic enzymes induced by VEGF, including MMP-2, urokinase-type plasminogen activator (uPA), and plasminogen activator inhibitor-1 (PAI-1). Tetraacetylphytosphingosine also suppresses the phosphorylation of p42/44 extracellular signal-regulated kinase and c-JNK in response to VEGF. Additionally, it eliminates the increase in intracellular calcium ions triggered by VEGF. In HaCaT cells, co-treatment with Tetraacetylphytosphingosine synergistically enhances UVB-induced apoptosis by modulating the levels of pro-apoptotic Bax and anti-apoptotic Bcl-2, achieved through the activation of caspases. |
| Molecular Weight | 485.65 |
| Formula | C26H47NO7 |
| Cas No. | 13018-48-9 |
| Smiles | [C@@H]([C@@H](CCCCCCCCCCCCCC)OC(C)=O)([C@H](COC(C)=O)NC(C)=O)OC(C)=O |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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