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HDAC-IN-100
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Catalog No. TP4413 Copy Product Info
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HDAC-IN-100 is a histone deacetylase inhibitor with IC50 values of 0.038 μM for HDAC1, 0.283 μM for HDAC2, and 0.586 μM for HDAC3. It functions as a chemosensitizer and apoptosis (apoptosis) inducer, activating caspase3/7 and counteracting Cisplatin resistance. HDAC-IN-100 exhibits antiproliferative effects in ovarian cancer and squamous carcinoma cells. It is valuable for research on ovarian cancer, squamous cell carcinoma, and Cisplatin-resistant squamous cell carcinoma.
HDAC-IN-100
Cas No. 2390474-88-9
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | Inquiry | Inquiry | |
| 50 mg | Inquiry | Inquiry | Inquiry |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | HDAC-IN-100 is a histone deacetylase inhibitor with IC50 values of 0.038 μM for HDAC1, 0.283 μM for HDAC2, and 0.586 μM for HDAC3. It functions as a chemosensitizer and apoptosis (apoptosis) inducer, activating caspase3/7 and counteracting Cisplatin resistance. HDAC-IN-100 exhibits antiproliferative effects in ovarian cancer and squamous carcinoma cells. It is valuable for research on ovarian cancer, squamous cell carcinoma, and Cisplatin-resistant squamous cell carcinoma. |
| Targets & IC50 | HDAC1:0.038 μM |
| In vitro | HDAC-IN-100 (compound 2a) reduces the viability of human cancer cells A2780 (IC 50 2.40 μM) and Cal27 (IC 50 1.60 μM) over 72 hours. When applied at concentrations of 0-100 μM for 18 hours, HDAC-IN-100 potently inhibits cell HDAC activity in A2780 (IC 50 0.48 μM) and Cal27 (IC 50 0.11 μM) cancer cells. The compound at 0.5 μM for 48 hours exhibits a strong synergistic effect with Cisplatin, decreasing viability of Cal27 cells and Cisplatin-resistant Cal27CisR cells, while completely reversing the Cisplatin resistance in Cal27CisR cells. Additionally, HDAC-IN-100 at 0.5 μM for 48 hours significantly increases apoptosis levels in both Cal27 and Cal27CisR cells. It also induces high acetylation of histone H3 within 24 hours in Cal27 and Cisplatin-resistant Cal27CisR cells. |
| Molecular Weight | 535.64 |
| Formula | C32H33N5O3 |
| Cas No. | 2390474-88-9 |
| Smiles | O=C(NC=1C=CC=CC1N)C2=CC=C(C=C2)CN(C(=O)C3=CC=C(C=C3)N(C)C)CC(=O)NCC=4C=CC=CC4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: HDAC-IN-100 in vitro | HDAC-IN-100 formula | HDAC-IN-100 molecular weight
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