Shopping Cart
Remove All
Your shopping cart is currently empty
Radotinib dihydrochloride
(Synonyms: IY-5511 dihydrochloride) Copy Product Info
🥰Excellent
Synonyms: IY-5511 dihydrochloride
Catalog No. T219231 Copy Product Info
🥰Excellent
Radotinib (IY-5511) dihydrochloride is an orally bioavailable and brain-penetrant selective tyrosine kinase Bcr-Abl1 inhibitor with an IC50 of 34 nM. It exhibits antiprion and antitumor activities by inhibiting tumor cell proliferation, inducing cell cycle arrest, and triggering apoptosis. Radotinib dihydrochloride is applicable in research on chronic myeloid leukemia, multiple myeloma, other tumors, and prion-related neurodegenerative diseases.
Radotinib dihydrochloride
Cas No. 926037-85-6
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | 10-14 weeks | 10-14 weeks | |
| 50 mg | Inquiry | 10-14 weeks | 10-14 weeks |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
Add to Quotation
For research use only—not for human use. No sales to individuals. Use as intended only.
Resource Download
Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Radotinib (IY-5511) dihydrochloride is an orally bioavailable and brain-penetrant selective tyrosine kinase Bcr-Abl1 inhibitor with an IC50 of 34 nM. It exhibits antiprion and antitumor activities by inhibiting tumor cell proliferation, inducing cell cycle arrest, and triggering apoptosis. Radotinib dihydrochloride is applicable in research on chronic myeloid leukemia, multiple myeloma, other tumors, and prion-related neurodegenerative diseases. |
| In vitro | Radotinib dihydrochloride (0-100 μM; 72 h) significantly inhibits the proliferation of various multiple myeloma cell lines, induces apoptosis, and causes cell cycle arrest by targeting the STAT3 and JAK2 signaling pathways. Additionally, Radotinib dihydrochloride (0-40 μM; 24 h) reduces PrPSc levels in ZW13-2 neuronal cells infected with pruritus strains 22L or 139A. |
| In vivo | Radotinib (100 mg/kg; administered via intraperitoneal injection; once daily, excluding weekends; for 21 days) dihydrochloride demonstrates antitumor activity in a nude mouse model implanted with IM-9 cells. Additionally, Radotinib (100 mg/kg; administered via oral gavage; for 4-8 weeks) dihydrochloride extends the survival time and reduces PrPSc deposition in hamsters infected with the 263K pruritus strain. |
| Synonyms | IY-5511 dihydrochloride |
| Molecular Weight | 603.43 |
| Formula | C27H23Cl2F3N8O |
| Cas No. | 926037-85-6 |
| Smiles | O=C(C1=CC=C(C)C(NC2=NC(C3=NC=CN=C3)=CC=N2)=C1)NC4=CC(C(F)(F)F)=CC(N5C=NC(C)=C5)=C4.Cl.Cl |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Preview
Related Tags: Radotinib dihydrochloride in vivo | Radotinib dihydrochloride in vitro | Radotinib dihydrochloride formula | Radotinib dihydrochloride molecular weight
Generate Quote
Catalog No.: Cas No.:
Add
| Size | Quantity | Unit Price | Amount | Operation |
|---|
Generate Quote
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2026 TargetMol Chemicals Inc. All Rights Reserved.