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COG-1410 acetate

Name: COG-1410 acetate
Brand: TargetMol
SKU: T30998L
Price: 113 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T30998L

Alias COG-1410 acetate(878009-24-6 Free base)

COG-1410 acetate is an apolipoprotein E-derived peptide and can be used in studies about neurological diseases.

COG-1410 acetate

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Purity: 99.61%

Catalog No. T30998LAlias COG-1410 acetate(878009-24-6 Free base)

COG-1410 acetate is an apolipoprotein E-derived peptide and can be used in studies about neurological diseases.

Pack Size	Price	Availability
1 mg	$113	In Stock
5 mg	$297	In Stock
10 mg	$497	In Stock
25 mg	$793	In Stock
50 mg	$1,130	In Stock
100 mg	$1,520	In Stock
500 mg	$2,970	In Stock

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Purity:99.61%

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COA MS HPLC

Product Introduction

Bioactivity

Description	COG-1410 acetate is an apolipoprotein E-derived peptide and can be used in studies about neurological diseases.
In vitro	In BV2 microglia cells, COG-1410 acetate (1-25 μM; 48 h) decreases the production and release of NO and TNFα[3].
In vivo	COG-1410 acetate (0.8 mg/kg; i.v.) improves vestibulomotor function, and decreases poststroke locomotor asymmetry, and infarct volume of the ipsilateral hemisphere in rats[1]. COG-1410 acetate (0.3-0.6 mg/kg; i.v.) exhibits significant improvement on a short-term test of vestibulomotor function and on a long-term test of spatial learning and memory in mice[3].
Synonyms	COG-1410 acetate(878009-24-6 Free base)

Chemical Properties

Molecular Weight	1468.83
Formula	C₆₆H₁₂₅N₂₁O₁₆
Smiles	CC(O)=O.CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC\N=C(\N)N)NC(=O)[C@H](CCCCN)NC(=O)C(C)(C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC\N=C(\N)N)NC(=O)[C@H](CC(C)C)NC(=O)C(C)(C)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(C)=O)C(N)=O
Color	White
Appearance	Solid
Sequence	Ala-Ser-Aib-Leu-Arg-Lys-Leu-Aib-Lys-Arg-Leu-Leu
Sequence Short	ASXLRKLXKRLL

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 146.88 mg/mL (100 mM), Sonication and heating are recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	0.6808 mL	3.4041 mL	6.8081 mL	34.0407 mL
5 mM	0.1362 mL	0.6808 mL	1.3616 mL	6.8081 mL
10 mM	0.0681 mL	0.3404 mL	0.6808 mL	3.4041 mL
20 mM	0.0340 mL	0.1702 mL	0.3404 mL	1.7020 mL
50 mM	0.0136 mL	0.0681 mL	0.1362 mL	0.6808 mL
100 mM	0.0068 mL	0.0340 mL	0.0681 mL	0.3404 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc