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COG-1410 acetate

Name: COG-1410 acetate
Brand: TargetMol
SKU: T30998L
Price: 113 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T30998L

Alias COG-1410 acetate(878009-24-6 Free base)

COG-1410 acetate is an apolipoprotein E-derived peptide and can be used in studies about neurological diseases.

COG-1410 acetate

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Purity: 99.61%

Catalog No. T30998LAlias COG-1410 acetate(878009-24-6 Free base)

COG-1410 acetate is an apolipoprotein E-derived peptide and can be used in studies about neurological diseases.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$113	-	In Stock
5 mg	$297	-	In Stock
10 mg	$497	-	In Stock
25 mg	$793	-	In Stock
50 mg	$1,130	-	In Stock
100 mg	$1,520	-	In Stock
500 mg	$2,970	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.61%

Appearance:Solid

Color:White

Resource Download

COA MS HPLC

Product Introduction

Bioactivity

Description	COG-1410 acetate is an apolipoprotein E-derived peptide and can be used in studies about neurological diseases.
In vitro	In BV2 microglia cells, COG-1410 acetate (1-25 μM; 48 h) decreases the production and release of NO and TNFα[3].
In vivo	COG-1410 acetate (0.8 mg/kg; i.v.) improves vestibulomotor function, and decreases poststroke locomotor asymmetry, and infarct volume of the ipsilateral hemisphere in rats[1]. COG-1410 acetate (0.3-0.6 mg/kg; i.v.) exhibits significant improvement on a short-term test of vestibulomotor function and on a long-term test of spatial learning and memory in mice[3].
Synonyms	COG-1410 acetate(878009-24-6 Free base)

Chemical Properties

Molecular Weight	1468.83
Formula	C₆₆H₁₂₅N₂₁O₁₆
Smiles	CC(O)=O.CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC\N=C(\N)N)NC(=O)[C@H](CCCCN)NC(=O)C(C)(C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC\N=C(\N)N)NC(=O)[C@H](CC(C)C)NC(=O)C(C)(C)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(C)=O)C(N)=O
Sequence	Ala-Ser-Aib-Leu-Arg-Lys-Leu-Aib-Lys-Arg-Leu-Leu
Sequence Short	ASXLRKLXKRLL

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 146.88 mg/mL (100 mM), Sonication and heating are recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	0.6808 mL	3.4041 mL	6.8081 mL	34.0407 mL
5 mM	0.1362 mL	0.6808 mL	1.3616 mL	6.8081 mL
10 mM	0.0681 mL	0.3404 mL	0.6808 mL	3.4041 mL
20 mM	0.0340 mL	0.1702 mL	0.3404 mL	1.7020 mL
50 mM	0.0136 mL	0.0681 mL	0.1362 mL	0.6808 mL
100 mM	0.0068 mL	0.0340 mL	0.0681 mL	0.3404 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc