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Tricin 7-O-glucoside
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Catalog No. TN5547Cas No. 32769-01-0
Alias Tricin 7-glucoside
Tricin 7-O-glucoside is a naturally occurring flavonoid with antidepressant and anxiolytic properties that increases the activity time of mice in the forced swim test. It protects the brain by attenuating brain I/R damage and attenuating blood-brain barrier (BBB) disruption, decreasing HMGB1 and NF-κB signaling pathways.
Tricin 7-O-glucoside
😃Good
Catalog No. TN5547Alias Tricin 7-glucosideCas No. 32769-01-0
Tricin 7-O-glucoside is a naturally occurring flavonoid with antidepressant and anxiolytic properties that increases the activity time of mice in the forced swim test. It protects the brain by attenuating brain I/R damage and attenuating blood-brain barrier (BBB) disruption, decreasing HMGB1 and NF-κB signaling pathways.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $564 | In Stock | |
| 5 mg | $1,729 | Backorder | |
| 1 mL x 10 mM (in DMSO) | $1,980 | Backorder |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Tricin 7-O-glucoside is a naturally occurring flavonoid with antidepressant and anxiolytic properties that increases the activity time of mice in the forced swim test. It protects the brain by attenuating brain I/R damage and attenuating blood-brain barrier (BBB) disruption, decreasing HMGB1 and NF-κB signaling pathways. |
| In vivo | Methods: The organic fraction (PcEA) was obtained from the hydroalcoholic extract of the aerial parts of P. coriacea and then subjected to chemical analysis and separation to obtain six fractions (PcEA, T1, T2, T1.1, T2.1 and T2.2). Male ICR mice were used to determine the antidepressant activity of the selected treatments (PcEA, T1, T2 and T1.1) based on the forced swim test (FST). The anxiolytic-like effects of various treatments (PcEA, T1, T2, T2.1 and T2.2) were determined using the elevated plus maze (EPM) test. Results: The organic fraction of P. coriacea reduced the anxiety-like behavior of mice and increased the activity time in the FST. After chemical separation, two compounds with antidepressant activity and anxiolytic-like effects were isolated from the species, namely T1.1 (Tricin 7-O-glucoside) and T2.2 (harmane). [1] |
| Alias | Tricin 7-glucoside |
| Molecular Weight | 492.43 |
| Formula | C23H24O12 |
| Cas No. | 32769-01-0 |
| Smiles | O=C1C=2C(OC(=C1)C3=CC(OC)=C(O)C(OC)=C3)=CC(O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)=CC2O |
| Relative Density. | 1.582 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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