Z19024498

Z19024498 serves as a thermosensitizer and can inhibit SAFB granule formation under heat stress conditions. Additionally, it enhances heat stress-induced apoptosis (Apoptosis) and exhibits anticancer activity against cervical cancer when used in conjunction with heat stress.

Z19024498 significantly enhances the inhibition of HeLa cell growth induced by heat stress when pre-incubated at 37°C for 1 hour, co-incubated under 43°C heat stress for 1 hour, and followed by recovery for 24 hours at 37°C without the compound. Additionally, Z19024498 inhibits the formation of independent SAFB granules in HeLa cells subjected to heat stress (IC50 = 10.7 μM) when used at concentrations of 0-20 μM, with pre-incubation at 37°C for 1 hour, followed by co-incubation at 43°C for 1 hour.

Administering Z19024498 (3 mg/kg; intraperitoneal injection; twice) on its own can slightly reduce tumor volume and extend survival in mice with HeLa xenografts. Combined with heat stress, it significantly inhibits tumor growth.