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VWK147
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Catalog No. T217958 Copy Product Info
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VWK147 is a second-generation HSP90 C-terminal domain (CTD) inhibitor. It acts on the CTD dimerization interface, preventing the dimerization of HSP90CTD, disrupting the binding of the co-chaperone protein PPID with HSP90CTD, and inhibiting dimerization-dependent functions of HSP90. VWK147 reduces the protein levels of HSP90 client proteins ULK1, RIPK1, and CDK4 without inducing a heat shock response. It induces cell death, including apoptosis (apoptosis), in both cisplatin-sensitive and resistant urothelial carcinoma cells. VWK147 causes LC3-II accumulation, inhibits autophagosome-lysosome fusion to block classical autophagy (autophagy), and triggers non-classical LC3 lipidation independent of the ULK1 and PIK3C3 complex. VWK147 is applicable to research on urothelial carcinoma.
VWK147
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | Inquiry | Inquiry | |
| 50 mg | Inquiry | Inquiry | Inquiry |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
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Storage & Solubility Information
| Description | VWK147 is a second-generation HSP90 C-terminal domain (CTD) inhibitor. It acts on the CTD dimerization interface, preventing the dimerization of HSP90CTD, disrupting the binding of the co-chaperone protein PPID with HSP90CTD, and inhibiting dimerization-dependent functions of HSP90. VWK147 reduces the protein levels of HSP90 client proteins ULK1, RIPK1, and CDK4 without inducing a heat shock response. It induces cell death, including apoptosis (apoptosis), in both cisplatin-sensitive and resistant urothelial carcinoma cells. VWK147 causes LC3-II accumulation, inhibits autophagosome-lysosome fusion to block classical autophagy (autophagy), and triggers non-classical LC3 lipidation independent of the ULK1 and PIK3C3 complex. VWK147 is applicable to research on urothelial carcinoma. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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