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JD-02
😃Good
Catalog No. T209229
JD-02 is a novel Hsp90 inhibitor that can induce autophagy and apoptosis in cells. Additionally, JD-02 elevates levels of reactive oxygen species (ROS).
JD-02
JD-02
😃Good
Catalog No. T209229
JD-02 is a novel Hsp90 inhibitor that can induce autophagy and apoptosis in cells. Additionally, JD-02 elevates levels of reactive oxygen species (ROS).
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | Inquiry | Inquiry | |
| 50 mg | Inquiry | Inquiry | Inquiry |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Chemical Properties
| Description | JD-02 is a novel Hsp90 inhibitor that can induce autophagy and apoptosis in cells. Additionally, JD-02 elevates levels of reactive oxygen species (ROS). |
| In vitro | JD-02 inhibits the growth of HTC116 and SW620 cells at concentrations of 0–2 μM over 24, 48, and 72 hours. Additionally, JD-02 at 1 μM for 36 to 72 hours induces G0/G1 phase arrest in these cells. Furthermore, JD-02 at 1 μM for 48 hours triggers apoptosis in HTC116 and SW620 cells. |
| In vivo | JD-02 (5, 10, and 20 mg/kg; intraperitoneal injection; 21 days) was effective in reducing tumor growth in the HCT116 cell xenograft mouse model.Animal Model: HCT116 cell xenograft mouse model Dosage: 5, 10, and 20 mg/kg Administration: Intravenous injection for 21 days Result: reduced tumor growth by 64.3%. |
| Formula | C23H32N6O2 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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