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BIW-8962
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Catalog No. T9901A-1923
BIW-8962 is a humanized anti-ganglioside GM2 antibody demonstrating ADCC/CDC activity against multiple myeloma cells. In murine xenograft models, BIW-8962 exhibits potent antitumor activity. This compound is applicable for research on cancers such as myeloma.
BIW-8962
BIW-8962
😃Good
Catalog No. T9901A-1923
BIW-8962 is a humanized anti-ganglioside GM2 antibody demonstrating ADCC/CDC activity against multiple myeloma cells. In murine xenograft models, BIW-8962 exhibits potent antitumor activity. This compound is applicable for research on cancers such as myeloma.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | Inquiry | Inquiry | Inquiry | |
| 5 mg | Inquiry | Inquiry | Inquiry |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Chemical Properties
| Description | BIW-8962 is a humanized anti-ganglioside GM2 antibody demonstrating ADCC/CDC activity against multiple myeloma cells. In murine xenograft models, BIW-8962 exhibits potent antitumor activity. This compound is applicable for research on cancers such as myeloma. |
| In vitro | BIW-8962 (0.01-1 μg/mL) exhibits ADCC activity in GM2-expressing SBC-3 cells. |
| In vivo | B BIW-8962 (0.1-10 mg/kg, administered intravenously every two weeks for 3-4 weeks) demonstrated anti-tumor activity in KMS-11 and OPM-2/GFP severe combined immunodeficiency (SCID) mouse models. In the SBC-3 SCID mouse model with natural killer cell depletion, BIW-8962 (0.1-10 μg/100μL, intravenously once daily on days 7, 14, 21, 28, and 35 post SBC-3 cell injection) effectively inhibited tumor metastasis across multiple organs, increased the number of apoptotic cells, and extended survival duration. |
Storage & Solubility Information
| Storage | store at low temperature | store at -20°C | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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