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Cuproptosis

Intracellular copper accumulation triggers the aggregation of mitochondrial lipoylated proteins and the destabilization of Fe–S cluster proteins, leading to a unique type of cell death termed cuproptosis.

Elesclomol
T6170488832-69-5
Elesclomol (STA-4783) is an oxidative stress inducer and a highly lipophilic copper ion carrier. Elesclomol induces apoptosis in tumor cells and is used in copper death related studies. Elesclomol also inhibits FDX1-mediated Fe-S cluster biosynthesis.
  • $34
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Disulfiram
T005497-77-8
Disulfiram (TETD) is an inhibitor of the acetaldehyde dehydrogenase ALDH, inhibiting hALDH1 and hALDH2 (IC50=0.15/1.45 μM) with specificity. Disulfiram is acutely sensitized to alcohol and also inhibits GSDMD pore formation.
  • $35
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Tiomolibdate diammonium
T1966815060-55-6
Tiomolibdate diammonium (NSC-286644) is an inhibitor of superoxide dismutase 1 (SOD1) exerting antiangiogenic and antitumor activities. Tiomolibdate diammonium inhibits the activities of cuproenzymes, including SOD1 and COX.
  • $35
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Cu(II)-Elesclomol
T848101224195-72-5
Cu(II)-Elesclomol is a complex formed by the anticancer agent Elesclomol and Cu(II), which selectively transports copper to mitochondria.Cu(II)-Elesclomol has anticancer activity, inhibits the growth of human leukemia K562 cells, and induces cell-cycle arrest, and is used in the study of leukemias.
  • $299
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Zinc pyrithione
T050213463-41-7
Zinc pyrithione (OM-1563), an antibacterial and antifungal agent can disrupt membrane transport by blocking the proton pump.
  • $35
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Penicillamine
T098352-67-5
Penicillamine (Artamine), possessing antineoplastic properties, induces apoptosis by a p53-mediated mechanism and inhibits angiogenesis by chelating with copper, a cofactor for angiogenesis. Artamine is a beta dimethyl analog of the amino acid cysteine. As a degradation product of penicillin antibiotics, Artamine chelates with heavy metals and increases their urinary excretion.
  • $42
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UM4118
T85322324530-92-9
UM4118 (N-quinolin-8-ylpyridine-2-carboxamide) is a copper ion carrier that triggers an atypical form of mitochondria-based cell death (cuproptosis).UM4118 can be used for the study of acute myeloid leukemia.UM4118 showed no significant effect on VEGF and b-FGF stimulated HMVEC proliferation with LC values of 0.013 and 0.018 μM, respectively.
  • $40
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Emeramide
T15213351994-94-0
Emeramide (BDTH2) is a thiol-redox antioxidant. It is also a heavy metal chelator.
  • $33
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tetrathiomolybdate
T7777416330-92-0
Tetrathiomolybdate (TM) promotes the dimerization of the metal-binding domain (WLN4) of the cellular copper efflux protein ATP7B through its characteristic sulfur bridge Mo2S6O2 cluster, and is used in the clinical treatment of Wilson's disease.
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NSC 689534
T84815907958-80-9
NSC 689534 forms a chelate with copper (Cu 2+), resulting in the NSC 689534/Cu 2+ complex, which is a potent inducer of oxidative stress and exhibits antitumor activity [1].
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8-10 weeks
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