Elesclomol (STA-4783) is an oxidative stress inducer and a highly lipophilic copper ion carrier. Elesclomol induces apoptosis in tumor cells and is used in copper death related studies. Elesclomol also inhibits FDX1-mediated Fe-S cluster biosynthesis.

Disulfiram (TETD) is an inhibitor of the acetaldehyde dehydrogenase ALDH, inhibiting hALDH1 and hALDH2 (IC50=0.15/1.45 μM) with specificity. Disulfiram is acutely sensitized to alcohol and also inhibits GSDMD pore formation.

Tiomolibdate diammonium (NSC-286644) is an inhibitor of superoxide dismutase 1 (SOD1) exerting antiangiogenic and antitumor activities. Tiomolibdate diammonium inhibits the activities of cuproenzymes, including SOD1 and COX.

Cu(II)-Elesclomol is a complex formed by the anticancer agent Elesclomol and Cu(II), which selectively transports copper to mitochondria.Cu(II)-Elesclomol has anticancer activity, inhibits the growth of human leukemia K562 cells, and induces cell-cycle arrest, and is used in the study of leukemias.

Zinc pyrithione (OM-1563), an antibacterial and antifungal agent can disrupt membrane transport by blocking the proton pump.

Penicillamine (Artamine), possessing antineoplastic properties, induces apoptosis by a p53-mediated mechanism and inhibits angiogenesis by chelating with copper, a cofactor for angiogenesis. Artamine is a beta dimethyl analog of the amino acid cysteine. As a degradation product of penicillin antibiotics, Artamine chelates with heavy metals and increases their urinary excretion.

UM4118 (N-quinolin-8-ylpyridine-2-carboxamide) is a copper ion carrier that triggers an atypical form of mitochondria-based cell death (cuproptosis).UM4118 can be used for the study of acute myeloid leukemia.UM4118 showed no significant effect on VEGF and b-FGF stimulated HMVEC proliferation with LC values of 0.013 and 0.018 μM, respectively.

Emeramide (BDTH2) is a thiol-redox antioxidant. It is also a heavy metal chelator.

Tetraethylenepentamine Pentahydrochloride is a high affinity copper and zinc chelator.

Copper ionophore I is an efficient carrier of copper ions that modulates intracellular copper levels to induce cuproptosis, with effects observed in cells such as 4T1 (IC50= 0.45 μM) and MDA-MB-231 (IC50= 1.21 μM). It elevates ROS, leading to mitochondrial dysfunction, and decreases the expression of proteins FDX1, DLAT, and LIAS. Additionally, it can activate immune-related pathways, enhancing T cell infiltration, making it a valuable compound for cancer research.

Tetrathiomolybdate (TM) promotes the dimerization of the metal-binding domain (WLN4) of the cellular copper efflux protein ATP7B through its characteristic sulfur bridge Mo2S6O2 cluster, and is used in the clinical treatment of Wilson's disease.

Cu(I) chelator 1 (Compound LH2) is a chelating agent specifically targeting the Cu(I) redox state. It inhibits the production of ROS.

NSC 689534 forms a chelate with copper (Cu 2+), resulting in the NSC 689534/Cu 2+ complex, which is a potent inducer of oxidative stress and exhibits antitumor activity [1].

Zinc pyrithione (Standard) is an analytical standard substance commonly used as a reference sample for zinc pyrithione research and analysis. Zinc pyrithione (OM-1563) disrupts membrane transport by inhibiting proton pumps, exhibiting antifungal and antibacterial activity. It also serves as a copper ion carrier and reagent for copper-induced cell death studies.

CuET is a metabolite of Disulfiram and acts as an inducer of copper-induced cell death (cuproptosis) and ferroptosis, exhibiting antitumor activity. It can directly interact with polyunsaturated phospholipids to generate free radicals, leading to lipid peroxidation. Through excessive copper accumulation, CuET induces cuproptosis, resulting in the aggregation of fatty acylated proteins and the loss of iron-sulfur cluster proteins. It also triggers ferroptosis via a copper-activated, radical-dependent pathway, with a lower dependence on iron accumulation, while altering lipid composition to increase cell sensitivity to oxidative damage. CuET elevates reactive oxygen species (ROS) and MDA levels within cancer cells. Both in vitro and in vivo, CuET demonstrates antitumor effects against non-small cell lung cancer and can be utilized in cancer-related research, such as studies on non-small cell lung cancer.