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NEURL1B-IN-1
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Catalog No. T218446 Copy Product Info
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NEURL1B-IN-1 is a NEURL1B degrader with a Kd of 46.2 nM. It binds to Arg422 within the NEURL1BNHR2 domain, triggering ubiquitination and proteasomal degradation, disrupting interaction with DLL1 and weakening the Notch signaling pathway. NEURL1B-IN-1 induces cell cycle arrest, apoptosis (apoptosis), and inhibits migration in liver cancer cells, making it useful for hepatocellular carcinoma research.
NEURL1B-IN-1
Cas No. 3068938-30-4
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | 10-14 weeks | 10-14 weeks | |
| 50 mg | Inquiry | 10-14 weeks | 10-14 weeks |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | NEURL1B-IN-1 is a NEURL1B degrader with a Kd of 46.2 nM. It binds to Arg422 within the NEURL1BNHR2 domain, triggering ubiquitination and proteasomal degradation, disrupting interaction with DLL1 and weakening the Notch signaling pathway. NEURL1B-IN-1 induces cell cycle arrest, apoptosis (apoptosis), and inhibits migration in liver cancer cells, making it useful for hepatocellular carcinoma research. |
| In vitro | NEURL1B-IN-1 (compound 1) effectively inhibits the viability of HepG2, Huh-7, and SK-Hep-1 liver cancer cells. At a concentration of 7.5 μM, it significantly suppresses colony formation in SK-Hep-1 (inhibition rate 93.6%) and Huh-7 (inhibition rate 83.9%) cells. This compound also markedly reduces DNA synthesis in SK-Hep-1 (by 83.9%) and Huh-7 (by 66.3%) cells. NEURL1B-IN-1 at 2.5-7.5 μM induces G2/M phase cell cycle arrest and apoptosis in SK-Hep-1 and Huh-7 cells, while inhibiting their migration and invasion. Furthermore, it downregulates the expression of CyclinB1 and phosphorylated cdc2 (Tyr17) proteins, and upregulates cleaved-PARP-1 and Bax proteins in these cell lines. At 7.5 μM, NEURL1B-IN-1 modulates epithelial-mesenchymal transition (EMT) by altering E-cadherin, Vimentin, and Slug protein expression in SK-Hep-1 and Huh-7 cells. |
| In vivo | Administered intraperitoneally at a dose of 30-60 mg/kg once daily for 60 consecutive days, NEURL1B-IN-1 effectively inhibits liver cancer tumor growth in SK-Hep-1 xenograft nude mice. |
| Molecular Weight | 478.62 |
| Formula | C30H38O5 |
| Cas No. | 3068938-30-4 |
| Smiles | C[C@]12[C@@]3([C@@]4([C@](OC3=O)(C[C@]5(C)[C@@](C4)(C(=C)CCC5)[H])[H])[H])C[C@](C1)(C6=C2[C@@]7([C@](C(=C)C(=O)O7)(CC[C@]6(C)O)[H])[H])[H] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Related Tags: NEURL1B-IN-1 in vivo | NEURL1B-IN-1 in vitro | NEURL1B-IN-1 formula | NEURL1B-IN-1 molecular weight
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