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Apoptosis inducer42 is an apoptosis inducer that triggers late-stage apoptosis and inhibits the secretion of IL-6. It exhibits high cytotoxicity toward cancer cells and is applicable in cancer research, including studies on colon cancer.

| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | 10-14 weeks | 10-14 weeks | |
| 50 mg | Inquiry | 10-14 weeks | 10-14 weeks |
| Description | Apoptosis inducer42 is an apoptosis inducer that triggers late-stage apoptosis and inhibits the secretion of IL-6. It exhibits high cytotoxicity toward cancer cells and is applicable in cancer research, including studies on colon cancer. |
| In vitro | Apoptosis inducer 42 (Compound 11) effectively inhibits the growth of SW480, SW620, PC3f, HCT116, and HaCaT cells with IC50 values of 5.1, 6.3, 6.0, 4.4, and 14.2 μM, respectively. At concentrations of 4.4-6.3 μM for 72 hours, it reduces the number of viable cells in SW480, SW620, PC3f, and HCT116 lines. Furthermore, Apoptosis inducer 42 activates late-stage apoptosis in these cells and suppresses IL-6 secretion. |
| Molecular Weight | 224.26 |
| Formula | C11H13OPS |
| Cas No. | 66685-93-6 |
| Smiles | O=C1CCP(=S)(C=2C=CC=CC2)CC1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
Dissolve 2 mg of the compound in 100 μL DMSO
to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
1) Add 100 μL of the DMSO
stock solution to 400 μL PEG300
and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O
and mix thoroughly until a homogeneous solution is obtained.
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