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PDE4B/D-IN-5
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Catalog No. T218329 Copy Product Info
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PDE4B/D-IN-5 (Compound P32) is a peripherally restrictive, orally active inhibitor of PDE4B and PDE4D with minimal blood-brain barrier penetration, exhibiting IC50 values of 3.4 nM and 2.2 nM, respectively. It suppresses TNF-α production and significantly reduces the Bax/Bcl2 ratio, mitigates oxidative stress by decreasing MPO activity and NO levels. PDE4B/D-IN-5 possesses anti-inflammatory, antioxidant, and anti-apoptotic (Anti-apoptotic) properties and is applicable for acute lung injury research.
PDE4B/D-IN-5
Cas No. 3064814-26-9
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | 10-14 weeks | 10-14 weeks | |
| 50 mg | Inquiry | 10-14 weeks | 10-14 weeks |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | PDE4B/D-IN-5 (Compound P32) is a peripherally restrictive, orally active inhibitor of PDE4B and PDE4D with minimal blood-brain barrier penetration, exhibiting IC50 values of 3.4 nM and 2.2 nM, respectively. It suppresses TNF-α production and significantly reduces the Bax/Bcl2 ratio, mitigates oxidative stress by decreasing MPO activity and NO levels. PDE4B/D-IN-5 possesses anti-inflammatory, antioxidant, and anti-apoptotic (Anti-apoptotic) properties and is applicable for acute lung injury research. |
| Targets & IC50 | PDE4B1:3.4 nM |
| In vitro | PDE4B/D-IN-5 effectively inhibits recombinant PDE4B1 in vitro with an IC50 of 3.4 nM in fluorescence polarization enzyme assays. The compound demonstrates high metabolic stability in rat liver microsomes, with 94.8% remaining after 60 minutes, a half-life of 5.5 hours, and a clearance rate as low as 0.0021 mL min−1 mg−1. Additionally, PDE4B/D-IN-5 (1-4 μM; 1 h) dose-dependently inhibits LPS-induced TNF-α production in RAW264.7 murine macrophages. |
| In vivo | PDE4B/D-IN-5, when administered orally at doses of 1-6 mg/kg, does not induce vomiting in beagle dogs. Administered via intraperitoneal injection at doses of 6-12 mg/kg, once daily for five consecutive days, PDE4B/D-IN-5 exhibits dose-dependent anti-inflammatory, antioxidative, and anti-apoptotic effects that alleviate acute lung injury induced by lipopolysaccharide (LPS) in male C57BL/6 mice through the cAMP-Epac pathway. |
| Molecular Weight | 425.43 |
| Formula | C22H21F2N5O2 |
| Cas No. | 3064814-26-9 |
| Smiles | O=C(O)CC1=CC=C(C=C1)NC2=CC=C3C(=C2)C(=NN3CC(F)F)C4=CC=NN4CC |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: PDE4B/D-IN-5 in vivo | PDE4B/D-IN-5 in vitro | PDE4B/D-IN-5 formula | PDE4B/D-IN-5 molecular weight
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