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C105SR

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Catalog No. T210448

C105SR is a cyclophilin D (CypD) inhibitor targeting peptidyl-prolyl cis-trans isomerase (PPIase). It has an IC50 value of 5 nM for inhibiting mitochondrial permeability transition pore (mPTP) opening. C105SR reduces apoptosis in hepatocytes induced by hypoxia-reoxygenation and boosts calcium retention capacity (CRC). It demonstrates hepatoprotective effects in a mouse model of ischemia-reperfusion injury (IRI).

C105SR

C105SR

😃Good
Catalog No. T210448
C105SR is a cyclophilin D (CypD) inhibitor targeting peptidyl-prolyl cis-trans isomerase (PPIase). It has an IC50 value of 5 nM for inhibiting mitochondrial permeability transition pore (mPTP) opening. C105SR reduces apoptosis in hepatocytes induced by hypoxia-reoxygenation and boosts calcium retention capacity (CRC). It demonstrates hepatoprotective effects in a mouse model of ischemia-reperfusion injury (IRI).
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Product Introduction

Bioactivity
Description
C105SR is a cyclophilin D (CypD) inhibitor targeting peptidyl-prolyl cis-trans isomerase (PPIase). It has an IC50 value of 5 nM for inhibiting mitochondrial permeability transition pore (mPTP) opening. C105SR reduces apoptosis in hepatocytes induced by hypoxia-reoxygenation and boosts calcium retention capacity (CRC). It demonstrates hepatoprotective effects in a mouse model of ischemia-reperfusion injury (IRI).
In vitro
C105SR at varying concentrations (0.5/1/5/10/50/100 μM) inhibits mitochondrial CypD PPIase activity. Additionally, C105SR at 1 μM for 4 hours under hypoxia (1% O2) followed by 1 hour of reoxygenation (21% O2) prevents mPTP opening. Furthermore, C105SR (0.5/1/5/10/50/100 μM) administered for 4 hours during hypoxia (1% O2) reduces hypoxia/reoxygenation-induced death in AML-12 cells.
In vivo
C105SR (50 mg/kg, administered subcutaneously, 24 hours prior to ischaemia–reperfusion injury (IRI) surgery, single dose) demonstrates a protective effect in a mouse model of hepatic ischaemia–reperfusion injury.'
Chemical Properties
Molecular Weight633.60
FormulaC32H33BrN4O3S
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
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