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Mouse Serum Albumin
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Catalog No. TRP-00630 Copy Product Info
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Mouse Serum Albumin is the most abundant protein in plasma and can leak into the brain parenchyma when the blood-brain barrier (BBB) is compromised. It induces astrocytes to convert to the A1 phenotype, significantly increases levels of Elovl1, promotes very-long-chain fatty acids (VLSFAs) secretion, and triggers neuronal lipid apoptosis through the endoplasmic reticulum stress response pathway. Additionally, microglia activated by Mouse Serum Albumin significantly trigger tau protein phosphorylation at multiple sites (Ser202/Thr205) via the NLRP3 inflammasome pathway. It also impairs spatial learning and memory in mice. Mouse Serum Albumin is useful for studying neurodegenerative diseases such as Alzheimer's disease (AD) and frontotemporal dementia (FTD).
Mouse Serum Albumin
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | Inquiry | Inquiry | |
| 50 mg | Inquiry | Inquiry | Inquiry |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Storage & Solubility Information
| Description | Mouse Serum Albumin is the most abundant protein in plasma and can leak into the brain parenchyma when the blood-brain barrier (BBB) is compromised. It induces astrocytes to convert to the A1 phenotype, significantly increases levels of Elovl1, promotes very-long-chain fatty acids (VLSFAs) secretion, and triggers neuronal lipid apoptosis through the endoplasmic reticulum stress response pathway. Additionally, microglia activated by Mouse Serum Albumin significantly trigger tau protein phosphorylation at multiple sites (Ser202/Thr205) via the NLRP3 inflammasome pathway. It also impairs spatial learning and memory in mice. Mouse Serum Albumin is useful for studying neurodegenerative diseases such as Alzheimer's disease (AD) and frontotemporal dementia (FTD). |
| In vitro | Mouse Serum Albumin at a concentration of 7 uM for 48 hours significantly reduces the average branch length, terminal stereomicroscope voxel count, and branch number in primary neurons. Additionally, when exposed for 24 hours, it upregulates Elovl1 mRNA and protein levels in primary astrocytes. Prolonged exposure for 48 hours induces significant neuronal apoptosis and increases TUNEL-positive cells in primary neurons. |
| In vivo | Intracerebral injection of Mouse Serum Albumin (1 μL per injection; administered intraventricularly; once every 4 days for 16 days) impairs spatial learning and memory abilities in mice. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Related Tags: Mouse Serum Albumin in vivo | Mouse Serum Albumin in vitro
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