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Y502-3888
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Catalog No. T218169 Copy Product Info
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Y502-3888 is a c-Myc inhibitor. It binds to the c-MycG4 structure, hindering c-Myc transcription, and reduces c-Myc expression at both the mRNA and protein levels. Y502-3888 decreases the viability of myeloma cells and induces apoptosis. It is applicable in the study of multiple myeloma.
Y502-3888
Cas No. 828292-11-1
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | 10-14 weeks | 10-14 weeks | |
| 50 mg | Inquiry | 10-14 weeks | 10-14 weeks |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Y502-3888 is a c-Myc inhibitor. It binds to the c-MycG4 structure, hindering c-Myc transcription, and reduces c-Myc expression at both the mRNA and protein levels. Y502-3888 decreases the viability of myeloma cells and induces apoptosis. It is applicable in the study of multiple myeloma. |
| In vitro | Y502-3888 (48 h) effectively and selectively inhibits the viability of human multiple myeloma RPMI 8226 and U266 cells, with IC 50 values of 12.67 μM and 7.03 μM, respectively, while exhibiting very low toxicity to non-malignant HEK293T cells. At concentrations of 5-20 μM over 48 hours, Y502-3888 induces apoptosis in a dose-dependent manner in human multiple myeloma U266 cells. Additionally, within the same concentration range and time, Y502-3888 downregulates c-Myc expression in U266 cells in a dose-dependent manner. |
| Molecular Weight | 410.45 |
| Formula | C19H18N6O3S |
| Cas No. | 828292-11-1 |
| Smiles | O=C(C=1SC=2N=CN3N=C(N=C3C2C1C)C=4C=CC=CC4N(=O)=O)N(CC)CC |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: Y502-3888 in vitro | Y502-3888 formula | Y502-3888 molecular weight
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