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POV-PC

Name: POV-PC
Brand: TargetMol
SKU: T35580
Rating: 4.5 (1 reviews)

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Catalog No. T35580Cas No. 121324-31-0

Alias POVPC

POV-PC is an oxidized phospholipid that inhibits VSMC growth under high serum conditions and induces apoptosis under low serum conditions. POVPC reduces NO production and expression of CD31 and endothelial NOS, triggering ferroptosis in vascular smooth muscle cells, promoting vascular calcification.

POV-PC

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Catalog No. T35580Alias POVPCCas No. 121324-31-0

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$339	35 days	35 days
5 mg	$1,430	35 days	35 days
10 mg	$2,660	35 days	35 days
25 mg	$5,720	35 days	35 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Appearance:Liquid

Color:Transparent

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Product Introduction

Bioactivity

Description	POV-PC is an oxidized phospholipid that inhibits VSMC growth under high serum conditions and induces apoptosis under low serum conditions. POVPC reduces NO production and expression of CD31 and endothelial NOS, triggering ferroptosis in vascular smooth muscle cells, promoting vascular calcification.
In vitro	POV-PC (0-100 µM; 13 h) Inhibited VSMC growth in a dose-dependent manner. POV-PC (50 µM; 2, 4, 6 h) induced apoptosis in a time-dependent manner. [1] POV-PC (30 μg/ml) enhanced endothelial barrier breakdown caused by heat-inactivated Staphylococcus aureus (HKSA). [2]
In vivo	In a mouse model of acute lung injury induced by intranasal injection of HKSA, intravenous injection of POV-PC(10 mg/kg) increased HKSA-induced BAL protein content and cell count, as well as tissue expression of TNF-α, KC, IL1β and CCL2. And promoted blood vessel leakage in Evans Blue's lung infiltration monitoring. [2]
Synonyms	POVPC

Chemical Properties

Molecular Weight	593.73
Formula	C₂₉H₅₆NO₉P
Cas No.	121324-31-0
Smiles	[C@H](COP(OCC[N+](C)(C)C)(=O)[O-])(COC(CCCCCCCCCCCCCCC)=O)OC(CCCC=O)=O
Relative Density.	no data available

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 8 mg/mL (13.47 mM), Sonication is recommended.

DMF: 8 mg/mL (13.47 mM), Sonication is recommended.

Ethanol: 8 mg/mL (13.47 mM), Sonication is recommended.

PBS (pH 7.2): 8 mg/mL (13.47 mM), Sonication is recommended.

Solution Preparation Table

DMSO/DMF/Ethanol/PBS (pH 7.2)

	1mg	5mg	10mg	50mg
1 mM	1.6843 mL	8.4213 mL	16.8427 mL	84.2134 mL
5 mM	0.3369 mL	1.6843 mL	3.3685 mL	16.8427 mL
10 mM	0.1684 mL	0.8421 mL	1.6843 mL	8.4213 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc