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POV-PC

Catalog No. T35580   CAS 121324-31-0

Oxidized low-density lipoprotien (oxLDL) particles contain low molecular weight species which are cytotoxic and pro-atherogenic. Many of these substances were recently isolated and purified from oxLDL, and identified as phosphatidylcholine species containing a fragmented, oxidized short-chain fatty acid remnant at the sn-2 position. 1-(Palmitoyl)-2-(5-oxovaleroyl)-phosphatidylcholine, or POV-PC, is one of the oxLDL species derived from 2-arachidonoyl or eicosapentanoyl phospholipids. POV-PC confers CD36 scavenger receptor binding affinity more potently than any hydroperoxy PC species, and may be one of the more important structural determinants of oxLDL. Treatment of cultured endothelial cells with POV-PC stimulates monocyte binding, stimulates intracellular cAMP production, and strongly inhibits the LPS-induced binding of neutrophils.

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POV-PC Chemical Structure
POV-PC, CAS 121324-31-0
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Oxidized low-density lipoprotien (oxLDL) particles contain low molecular weight species which are cytotoxic and pro-atherogenic. Many of these substances were recently isolated and purified from oxLDL, and identified as phosphatidylcholine species containing a fragmented, oxidized short-chain fatty acid remnant at the sn-2 position. 1-(Palmitoyl)-2-(5-oxovaleroyl)-phosphatidylcholine, or POV-PC, is one of the oxLDL species derived from 2-arachidonoyl or eicosapentanoyl phospholipids. POV-PC confers CD36 scavenger receptor binding affinity more potently than any hydroperoxy PC species, and may be one of the more important structural determinants of oxLDL. Treatment of cultured endothelial cells with POV-PC stimulates monocyte binding, stimulates intracellular cAMP production, and strongly inhibits the LPS-induced binding of neutrophils.
Molecular Weight 593.73
Formula C29H56NO9P
CAS No. 121324-31-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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DMSO: 10 mg/mL

DMF: 15 mg/mL

Ethanol: 30 mg/mL

PBS (pH 7.2): 10 mg/mL

( < 1 mg/ml refers to the product slightly soluble or insoluble )

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Keywords

POV-PC 121324-31-0 POV PC POVPC inhibitor inhibit

 

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