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HIF-2α-IN-17
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Catalog No. T218070 Copy Product Info
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HIF-2α-IN-17 is a selective inhibitor of hypoxia-inducible factor 2 alpha (HIF2α) that binds to the PAS-B domain of HIF2α. It disrupts the interaction between HIF2α and the molecular chaperone Hsp70, leading to the proteasomal degradation of HIF2α. HIF-2α-IN-17 exhibits antitumor activity by inducing apoptosis in cancer cells and can be utilized in research on cancers such as clear cell renal carcinoma.
Cas No. 861212-49-9
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | 10-14 weeks | 10-14 weeks | |
| 50 mg | Inquiry | 10-14 weeks | 10-14 weeks |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | HIF-2α-IN-17 is a selective inhibitor of hypoxia-inducible factor 2 alpha (HIF2α) that binds to the PAS-B domain of HIF2α. It disrupts the interaction between HIF2α and the molecular chaperone Hsp70, leading to the proteasomal degradation of HIF2α. HIF-2α-IN-17 exhibits antitumor activity by inducing apoptosis in cancer cells and can be utilized in research on cancers such as clear cell renal carcinoma. |
| In vitro | HIF-2α-IN-17 (Compound-c2) selectively inhibits the viability of VHL-deficient clear cell renal cell carcinoma (ccRCC) cell lines (786-O, A498) at concentrations of 0-30 μM for 24 hours, with no effect on VHL-positive Caki-1 cells or normal HEK293 cells. At concentrations of 5-30 μM for 24 hours, HIF-2α-IN-17 induces apoptosis in 786-O cells by activating caspase-3 and caspase-7. Additionally, it suppresses HIF2α transcriptional activity in 786-O cells and reduces the expression levels of HIF2α target genes (VEGF, NDRG2, CCND1, GLUT1) at 0-30 μM for 8-24 hours. |
| Molecular Weight | 311.31 |
| Formula | C17H14FN3O2 |
| Cas No. | 861212-49-9 |
| Smiles | O=C(N=C1C=2C=CC=CC2NC(=O)N1CC)C3=CC=C(F)C=C3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: HIF-2α-IN-17 chemical structure | HIF-2α-IN-17 in vitro | HIF-2α-IN-17 formula | HIF-2α-IN-17 molecular weight
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