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HDAC11-IN-5
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Catalog No. T218931 Copy Product Info
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HDAC11-IN-5 is a potent and selective HDAC11 inhibitor with oral bioavailability, exhibiting an IC50 of 0.021 μM. This compound enhances fatty acid acylation levels of substrate SHMT2 in acute myeloid leukemia (AML) cells. It induces apoptosis, G1 phase cell cycle arrest, ferroptosis, reactive oxygen species (ROS) production, and terminal myeloid differentiation in AML cells. Additionally, HDAC11-IN-5 demonstrates antitumor activity in an MLL-AF9-induced mouse AML model, making it useful for cancer research, particularly in the context of acute myeloid leukemia.
HDAC11-IN-5
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | Inquiry | Inquiry | |
| 50 mg | Inquiry | Inquiry | Inquiry |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Storage & Solubility Information
| Description | HDAC11-IN-5 is a potent and selective HDAC11 inhibitor with oral bioavailability, exhibiting an IC50 of 0.021 μM. This compound enhances fatty acid acylation levels of substrate SHMT2 in acute myeloid leukemia (AML) cells. It induces apoptosis, G1 phase cell cycle arrest, ferroptosis, reactive oxygen species (ROS) production, and terminal myeloid differentiation in AML cells. Additionally, HDAC11-IN-5 demonstrates antitumor activity in an MLL-AF9-induced mouse AML model, making it useful for cancer research, particularly in the context of acute myeloid leukemia. |
| Targets & IC50 | HDAC11:0.021 μM |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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