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Harmalol
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Catalog No. T8770Cas No. 525-57-5
Alias Harmidol
Harmalol (Harmidol) is a bioactive beta-carboline and a member of the harmala alkaloids
Harmalol
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Purity: 98.94%
Catalog No. T8770Alias HarmidolCas No. 525-57-5
Harmalol (Harmidol) is a bioactive beta-carboline and a member of the harmala alkaloids
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $76 | In Stock | In Stock | |
| 5 mg | $162 | In Stock | In Stock | |
| 10 mg | $223 | In Stock | In Stock | |
| 25 mg | $401 | In Stock | In Stock | |
| 50 mg | $597 | In Stock | In Stock | |
| 100 mg | $849 | In Stock | In Stock | |
| 500 mg | $1,730 | In Stock | In Stock | |
| 1 mL x 10 mM (in DMSO) | $139 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Batch Information
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Purity:98.94%
Appearance:Solid
Color:Yellow
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Product Introduction
Harmalol AI Summary
Harmalol exhibits a range of bioactivities across different biological targets. Despite showing a low binding affinity towards the 5-hydroxytryptamine 5A receptor (Ki > 10000.0 nM), it acts as an inhibitor for cyclin-dependent kinase 5 (CDK 5) with a 15.0% inhibition rate and cyclin-dependent kinase 2 (CDK 2) with a 13.0% inhibition rate at 50 µM. It significantly inhibits the SRC2-3 interaction at the androgen receptor ligand binding domain with an inhibition percentage of 162.0% at 50 µM over 2 hours.
In antiplatelet activity assays, it inhibits collagen-induced platelet aggregation in rabbit platelets with an IC50 value greater than 130,000.0 nM. It also demonstrates notable acetylcholinesterase (AChE) inhibition, showing an IC50 of 11280.0 nM and inhibiting electric eel AChE activity by 88.61% at 10^-4 M, and human AChE by 49.66% at the same concentration.
Harmalol inhibits various enzyme activities, including native rhodanese, soluble pig heart MDH, Escherichia coli GroEL/GroES-mediated refolding activities, and ATPase activity of Escherichia coli GroEL, with IC50 values ranging from 9700.0 nM to >250000.0 nM and inhibition percentages from 82.0% to 87.0%. Additionally, it shows antifungal activity against Candida albicans with a MIC value of 750.0 µg/mL (72 hours incubation).
Overall, Harmalol has a complex bioactivity profile, influencing multiple signaling pathways and enzyme activities, suggesting considerable potential for therapeutic applications in various disease contexts..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Harmalol (Harmidol) is a bioactive beta-carboline and a member of the harmala alkaloids |
| Synonyms | Harmidol |
| Molecular Weight | 200.24 |
| Formula | C12H12N2O |
| Cas No. | 525-57-5 |
| Smiles | CC=1C2=C(C=3C(N2)=CC(O)=CC3)CCN1 |
| Relative Density. | 1.28g/cm3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 79.17 mg/mL (395.38 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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