α5β1

Rad51-in-1 is a derivative of B02 and an effective inhibitor of Rad51.

K34c hydrochloride is an alpha5β1 integrin antagonist for glioblastoma study.

ATN-161 trifluoroacetate salt (ATN-161 TFA salt) is a novel integrin α5β1 antagonist that inhibits angiogenesis and growth of liver metastases and improves survival in a murine model.

α5β1integrin agonist-2 (Compound 2) is a highly selective agonist of the α5β1 integrin, with an EC50 of 45.98 nM. It enhances extracellular matrix adhesion and activates the Akt/ERK signaling pathways. This compound shows potential for research in ischemic stroke.

α5β1 integrin agonist-1 is an α5β1 integrin agonist that selectively delivers 5-FU to tumour cells and induces tumour cell death.

SBP-7455 potently inhibited ULK1/2 enzymatic activity in vitro and in cells, reduced the viability of TNBC cells and had oral bioavailability in mice.

ATB107 hydrochloride is a novel and potent inhibitor of indole-3-glycerol phosphate synthase (IGPS) with a KD of 3 μM.

ot-730 HCl is a novel selective beta blocker prodrug for the study of ocular diseases.

1-Methyl-1H-indole-5-carboxylic acid ,with CAS No. 186129-25-9, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 1-Methyl-1H-indole-5-carboxylic acid provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

Dodecane is a straight-chain alkane primarily used as a fuel, reference standard substance, and solvent, capable of upregulating TNF-α expression in rat skin irritation.

Antiviral Agent 51 (compound A) is a fucoidan and antiviral agent that inhibits Human alphaherpesvirus 1 and interacts with the RNA-dependent RNA polymerase (RdRp) of DENV-2, making it useful for studying dengue virus.

CDK8/19-IN-51 is an orally active and highly effective dual inhibitor of CDK8 and CDK19, with anticancer activity. Its IC50 values for CDK8 and CDK19 are 5.1 nM and 5.6 nM, respectively. It is used in studies of colorectal and gastric cancers.

[5-(Tert-butyl)-2-thienyl](1-pyrrolidinyl)methanone ,with CAS No. 260354-92-5, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. [5-(Tert-butyl)-2-thienyl](1-pyrrolidinyl)methanone provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

3-Phenyl-4,5-dihydro-1H-pyrazol-5-one ,with CAS No. 145130-50-3, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 3-Phenyl-4,5-dihydro-1H-pyrazol-5-one provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

2-Amino-5-ethylthio-1,3,4-thiadiazole ,with CAS No. 25660-70-2, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 2-Amino-5-ethylthio-1,3,4-thiadiazole provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

HDAC-IN-51 is an HDAC inhibitor.

LUN42518 HCl is an analogue of phentolamine. Phentolamine is a nonselective alpha-adrenergic antagonist.

5-Methoxy-1-indanone ,with CAS No. 5111-70-6, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 5-Methoxy-1-indanone provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

2-Bromo-5-phenylthiazole ,with CAS No. 133311-51-0, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 2-Bromo-5-phenylthiazole provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

JohnPhos ,with CAS No. 224311-51-7, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. JohnPhos provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

cis-tert-butyl 8-fluoro-3,4,4a,5-tetrahydro-1H-pyrido[4,3-b]indole-2(9bH)-carboxylate ,with CAS No. 1251015-03-8, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. cis-tert-butyl 8-fluoro-3,4,4a,5-tetrahydro-1H-pyrido[4,3-b]indole-2(9bH)-carboxylate provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

4-(5-Methyl-1,2,4-oxadiazol-3-yl)benzoic acid ,with CAS No. 95124-68-8, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 4-(5-Methyl-1,2,4-oxadiazol-3-yl)benzoic acid provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

Ebselen (CCG-39161) is a organoselenium compound with anti-inflammatory, anti-oxidant and cytoprotective activity. Ebselen acts as a glutathione peroxidase mimetic and is thereby able to prevent cellular damage induced by reactive oxygen species (ROS). In addition, this agent inhibits the activity of a variety of enzymes including nitric oxide synthase (NOS), 5-lipoxygenase, cyclooxygenase, protein kinase C (PKC), NADPH oxidase and gastric H+/K+-ATPase. Furthermore, ebselen may be neuroprotective due to its ability to neutralize free radicals upon NMDA receptor activation thus, reducing lipoperoxidation mediated by glutamate-induced excitotoxicity.

AGX51 is an antagonist of inhibitor of DNA binding (ID) proteins. AGX51 treatment lead to pan-Id degradation, cell cycle arrest, and cell death.