α5β1

K34c hydrochloride is an alpha5β1 integrin antagonist for glioblastoma study.

Rad51-in-1 is a derivative of B02 and an effective inhibitor of Rad51.

5-Fluorouracil-D1 is the deuterated form of 5-Fluorouracil. 5-Fluorouracil (T0984) (5-FU) is a nucleoside antimetabolite, a uracil analog with potent antitumor properties. It interferes with pyrimidine synthesis by inhibiting thymidylate synthase, depleting the intracellular dTTP pool. 5-Fluorouracil (T0984) induces apoptosis and can be used as a chemosensitizer. Additionally, it inhibits the HIV virus and disrupts exosome-specific rRNA.

ATN-161 trifluoroacetate salt (ATN-161 TFA salt) is a novel integrin α5β1 antagonist that inhibits angiogenesis and growth of liver metastases and improves survival in a murine model.

ATN-161 is an integrin α5β1 binding peptide and antagonist that inhibits VEGF-induced hCECs migration and angiogenesis. ATN-161 also suppresses spike protein interaction with integrin α5β1 and may be employed against SARS-CoV-2 infection.

Volociximab (M200) is an IgG4 monoclonal antibody targeting the α5β1 integrin , with antiangiogenic, antitumor and anticancer activity, inhibits the growth of rabbit VX2 tumors and is used to study solid tumors.

α5β1integrin agonist-2 (Compound 2) is a highly selective agonist of the α5β1 integrin, with an EC50 of 45.98 nM. It enhances extracellular matrix adhesion and activates the Akt/ERK signaling pathways. This compound shows potential for research in ischemic stroke.

α5β1integrin-IN-1 (compound 65) is a potent and selective α5β1 integrin inhibitor with a pIC50 of 9.4. Its selectivity for α5β1 is over 10,000 times greater than for αVβ3 (pIC50 of 5.5). This compound reduces airway smooth muscle (ASM) tension by disrupting intercellular connections. In rodents, α5β1integrin-IN-1 demonstrates excellent inhalation pharmacokinetic properties and is applicable in asthma research.

α5β1 integrin agonist-1 is an α5β1 integrin agonist that selectively delivers 5-FU to tumour cells and induces tumour cell death.

Anti-Integrin α5β1 Antibody is an antibody targeting Integrin α5β1 and can be used for life science research.

SBP-7455 potently inhibited ULK1/2 enzymatic activity in vitro and in cells, reduced the viability of TNBC cells and had oral bioavailability in mice.

ATB107 hydrochloride is a novel and potent inhibitor of indole-3-glycerol phosphate synthase (IGPS) with a KD of 3 μM.

ot-730 HCl is a novel selective beta blocker prodrug for the study of ocular diseases.

1-Methyl-1H-indole-5-carboxylic acid ,with CAS No. 186129-25-9, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 1-Methyl-1H-indole-5-carboxylic acid provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

Dodecane is a straight-chain alkane primarily used as a fuel, reference standard substance, and solvent, capable of upregulating TNF-α expression in rat skin irritation.

Antiviral Agent 51 (compound A) is a fucoidan and antiviral agent that inhibits Human alphaherpesvirus 1 and interacts with the RNA-dependent RNA polymerase (RdRp) of DENV-2, making it useful for studying dengue virus.

CDK8/19-IN-51 is an orally active and highly effective dual inhibitor of CDK8 and CDK19, with anticancer activity. Its IC50 values for CDK8 and CDK19 are 5.1 nM and 5.6 nM, respectively. It is used in studies of colorectal and gastric cancers.

[5-(Tert-butyl)-2-thienyl](1-pyrrolidinyl)methanone ,with CAS No. 260354-92-5, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. [5-(Tert-butyl)-2-thienyl](1-pyrrolidinyl)methanone provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

3-Phenyl-4,5-dihydro-1H-pyrazol-5-one ,with CAS No. 145130-50-3, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 3-Phenyl-4,5-dihydro-1H-pyrazol-5-one provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

2-Amino-5-ethylthio-1,3,4-thiadiazole ,with CAS No. 25660-70-2, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 2-Amino-5-ethylthio-1,3,4-thiadiazole provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

HDAC-IN-51 is an HDAC inhibitor.

LUN42518 HCl is an analogue of phentolamine. Phentolamine is a nonselective alpha-adrenergic antagonist.

5-Methoxy-1-indanone ,with CAS No. 5111-70-6, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 5-Methoxy-1-indanone provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

2-Bromo-5-phenylthiazole ,with CAS No. 133311-51-0, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 2-Bromo-5-phenylthiazole provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.