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BMS-986497

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Catalog No. T207728
Alias ORM-6151

BMS-986497 (ORM-6151) is a CD33-targeted antibody conjugated with a GSPT1 degrader. It delivers the GSPT1 degrader SMol006 to CD33-expressing cells, inducing the degradation of the GSPT1 protein. BMS-986497 holds potential for research in acute myeloid leukemia (AML).

BMS-986497

BMS-986497

😃Good
Catalog No. T207728Alias ORM-6151
BMS-986497 (ORM-6151) is a CD33-targeted antibody conjugated with a GSPT1 degrader. It delivers the GSPT1 degrader SMol006 to CD33-expressing cells, inducing the degradation of the GSPT1 protein. BMS-986497 holds potential for research in acute myeloid leukemia (AML).
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Product Introduction

Bioactivity
Description
BMS-986497 (ORM-6151) is a CD33-targeted antibody conjugated with a GSPT1 degrader. It delivers the GSPT1 degrader SMol006 to CD33-expressing cells, inducing the degradation of the GSPT1 protein. BMS-986497 holds potential for research in acute myeloid leukemia (AML).
SynonymsORM-6151
Chemical Properties
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
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