fac

Ammonium iron(III) citrate (Ferric ammonium citrate) is a physiological form of non-ferritin-bound iron that causes intracellular iron overload leading to cellular ferroptosis and enhances protein production.

Compound 6, fac-[Re(CO)3(L6)(H2O)][NO3], a rhenium(I) tricarbonyl aqua complex, serves as an anticancer agent by disrupting mitochondrial function. It exhibits cytotoxicity against prostate cancer cells with an IC50 of 50 nM in PC-3 cells. This compound predominantly localizes in the nucleus, impairs ATP production, and induces apoptosis in PC3 cells without causing necrosis, pyroptosis, or autophagy [1].

Fac-[Re(CO)3(L3)(H2O)][NO3] (Compound 3), a rhenium(I) tricarbonyl aqua complex, acts as an anticancer agent through the induction of mitochondrial dysfunction. It exhibits cytotoxicity against prostate cancer cells, demonstrating an IC50 value of 0.32 μM in PC-3 cells. This compound predominantly localizes to the mitochondria, reducing ATP production and triggering paraptosis in PC3 cells, while not initiating necrosis, apoptosis, or autophagy [1].

Defactinib (VS-6063) is a second-generation inhibitor of FAK that inhibits FAK phosphorylation at the Tyr397 site. Defactinib has potential antitumor activity.

Tofacitinib (Tasocitinib) is a Janus kinase inhibitor that inhibits JAK3/2/1 (IC50=1/20/112 nM) and is orally active. Tofacitinib is used for the treatment of moderate to severe rheumatoid arthritis.

Afacifenacin (SMP-986) fumarate is an M3 muscarinic receptor-selective antagonist used in the study of ischemic heart disease, urinary incontinence and cystitis and other disorders.

(Rel)-Factor B-IN-5 is a complement factor B inhibitor that can be used to study diseases associated with activation of the alternative complement pathway.

Sulfacetamide sodium monohydrate, a sulfonamide antibiotic, has been investigated for the treatment of rosacea and pityriasis versicolor.

Sulfacetamide sodium (Sulamyd sodium) is an anti-infective agent. It is used topically to treat orally for urinary tract infections and skin infections.

Phthalylsulfacetamide (Tamid) is a sulfonamide antibiotic used for topical application to the skin and the conjunctiva.

Surfactin is a potent cyclic lipopeptide biosurfactants that mediates flux of mono-and divalent cations, such as calcium, across lipid bilayer membranes, with anti-bacterial, anti-fungal, antimycoplasma and hemolytic effects.

Cefaclor monohydrate (Cefaclorum) is a beta-lactam, second-generation cephalosporin antibiotic with bactericidal activity.

Elfacos EHP (2-ethylhexyl palmitate) is a fatty acid ester derived from 2-ethyl hexanol and palmitic acid and can be used in cosmetic formulations.

Sulfacetamide (NSC-63871) is used to treat blepharitis or conjunctivitis (in eye-drop solution) by limiting the presence of folic acid which bacteria need to survive. sulfacetamide may serve as a treatment for mild forms of hidradenitis suppurativa. It is also used to control acne.

Guanfacine hydrochloride (Intuniv) is a centrally acting antihypertensive agent with specificity towards ADRENERGIC ALPHA-2 RECEPTORS.

Sulfachloropyridazine (Sulfachlorpyridazine) is a sulfonamide antimicrobial used for urinary tract infections and in veterinary medicine.

Tofacitinib Citrate (CP-690550 citrate) is a a potent, cell-permeable inhibitor of JAK1/2/3 (IC50s: 1/20/112 nM).

Sulfachloropyrazine sodium(Sulfachloropyrazine) is an antiprotozoal,with antibacterial and anticoccidial effects

Factor B-IN-5 is a complement factor B inhibitor, which can be used to study immune-related diseases.

Sulfacarbamide (Sulfanilylurea) is a blood sugar-lowering agent.

Alfacalcidol-D6 is a deuterated Alfacalcidol. Alfacalcidol is a non-selective VDR activator medication.

Impurity of Alfacalcidol is an impurity of Alfacalcidol. Alfacalcidol is a non-selective VDR activator medication.

NFAT Transcription Factor Regulator-1 is a synthesis inhibitor of IL-2 with an IC50 of 182 nM.

Euphorbia factor L25 is a useful organic compound for research related to life sciences and the catalog number is T125089.