c 5

3-(9-Chloro-3-methyl-4-oxoisoxazolo[4,3-c]quinolin-5(4H)-yl)-N-(3,4,5-trimethoxyphenyl)benzeneacetamide inhibits multidrug resistance protein (MRP1).

NSC 55655 (5-[(2-Nitrophenyl)methylene]-2,4-thiazolidinedione) possesses antimicrobial and antioxidant activities and inhibits the proliferation of B. subtilis, S. aureus, K. pneumonia, E. coli, S. typhi , A. niger and C. albicans. A. niger and C. albicans, and can be used in diabetes mellitus.

5-ETHYL-4,5,6,7-TETRAHYDRO-THIAZOLO[5,4-C]PYRIDIN-2-YLAMINE targets PLK1.

UNC 569 hydrochloride is a reversible and ATP-competitive inhibitor of Mer with an IC50 of 2.9 nM and a Ki of 4.3 nM. UNC 569 hydrochloride inhibits Axl and Tyro3 with IC50s of 37 nM and 48 nM, respectively. UNC 569 hydrochloride can be used in studies about acute lymphoblastic leukemia and atypical teratoid rhabdoid tumors.

Phloretin 3',5'-Di-C-glucoside is a useful organic compound for research related to life sciences and the catalog number is T124963.

(3S)Lenalidomide-5-Pip-C-Pip-2C-Pip serves as an E3 Ligase Ligand-Linker Conjugate and is utilized in the synthesis of PROTAC Cbl-b-IN-1.

Thalidomide 5-Pip-C-oxotetrahydropyrimidin-bromophenyl, an E3 Ligase Ligand-Linker Conjugate, serves as a precursor for synthesizing PROTAC GSPT1 degrader-2.

C-lock-G5-DUO-5 is a Drug-linker. DUO-5 is a microtubule inhibitor with anti-cancer activity. It is connected to C-lock-G5 through a stable covalent irreversible linkage, re-introducing covalent bonding, achieving better stability and improved PK characteristics. It can be used for the preparation and synthesis of related products such as BA1301.

N-Ac-Cys-C-lock-G5-DUO-5 is a part of ADC. DUO-5 is a microtubule inhibitor and a new type of toxin molecule with anti-cancer activity.

7-Methoxy-8-(3-morpholin-4-ylpropoxy)-2,3-dihydroimidazo[1,2-c]quinazolin-5-amine is a building block.1It has been used in the synthesis of PI3K inhibitors. 1.Scott, W.J., Hentemann, M.F., Rowley, R.B., et al.Discovery and SAR of novel 2,3-dihydroimidazo[1,2-c]quinazoline PI3K inhibitors: Identification of copanlisib (BAY 80-6946)ChemMedChem.11(14)1517-1530(2016)

5-heptyl-DNJ is an effective GAA agonist with a Ki of 0.0047 μM. 5-C-heptyl-DNJ increases GAA activities through chaperrone effects [1].

Cathepsin C-IN-5 (compound SF38) is a potent, selective, and orally active Cathepsin C inhibitor with an IC50 of 59.9 nM for Cat C, and significantly lower potency against Cat L (4.26 µM), Cat S, Cat B, and Cat K (all >5 µM). It reduces Cat C activity in bone marrow and blood, diminishes NSPs activation, and exhibits anti-inflammatory activity [1].

1H-Imidazo[4,5-c]quinoline, 1-(2-methylpropyl)-, 5-oxide is a useful organic compound for research related to life sciences and the catalog number is T64577.

5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic acid hydrochloride is a useful organic compound for research related to life sciences. The catalog number is T66095 and the CAS number is 720720-96-7.

Dichloro[1,3-bis(2,4,6-trimethylphenyl)-2-imidazolidinylidene][[5-[(dimethylamino)sulfonyl]-2-(1-methylethoxy-O)phenyl]methylene-C]ruthenium(II) is a useful organic compound for research related to life sciences and the catalog number is T66135.

tert-Butyl 4,6-dihydropyrrolo[3,4-c]pyrazole-5(2H)-carboxylate is a useful organic compound for research related to life sciences. The catalog number is T66374 and the CAS number is 1280210-79-8.

5-Chloro-3-phenylbenzo[c]isoxazole is a useful organic compound for research related to life sciences. The catalog number is T66589 and the CAS number is 719-64-2.

(1'R,3a'R,8a'S,9'S,9a'S)-1'-Methyl-3'-oxo-N,N-diphenyl-3',3a',5',7',8',8a',9',9a'-octahydro-1'H-spiro[[1,3]dioxolane-2,6'-naphtho[2,3-c]furan]-9'-carboxamide is a useful organic compound for research related to life sciences. The catalog number is T67324 and the CAS number is 900160-98-7.

c-Myc Inhibitor 5 (DA3) is a fluorescent bispurine compound with a long-chain bridge that selectively binds to the c-MYC G-quadruplex, exhibiting a dissociation constant (K D) of 16 μM. Unlike other G4-driven oncogenes, this inhibitor specifically suppresses c-MYC expression [1].

5'-ODMT cEt N-Bzm5 C Phosphoramidite Amidite is a potent nucleic acid analog and a modified antisense oligonucleotide [1].

6-Methoxypurine-9-β-D-5'(R)-C-methylriboside, an analog of hypoxanthine—a purine base predominantly found in muscle tissue and a metabolite generated when purine oxidase acts on xanthine—displays anti-inflammatory properties and functions as a potential endogenous poly(ADP-ribose) polymerase (PARP) inhibitor. Its cytoprotective role is underscored by its ability to inhibit PARP activity, thus preventing peroxynitrite-induced mitochondrial depolarization and subsequent superoxide production. Furthermore, hypoxanthine serves as a biomarker for hypoxia [1] [2].

4-Amino-5-cyano-1-(2-β-C-methyl-β-D-ribofuranosyl)-7H-pyrrolo[2.3-d]pyrimidine, a purine nucleoside analogue, exhibits widespread antitumor efficacy, particularly against indolent lymphoid malignancies. Its anticancer properties primarily stem from the inhibition of DNA synthesis and the induction of apoptosis, among other mechanisms [1].

5'(R)-C-Methyl-5-fluorouridine, a uridine analogue, potentially exhibits antiepileptic properties. Its analogues play a crucial role in researching anticonvulsant and anxiolytic effects and are essential in developing new antihypertensive agents [1].

5'-O-Benzoyl-3'-O-(4-methoxybenzyl)-2'-O,4'-C-methyleneuridine is a purine nucleoside analog with broad antitumor activity, primarily targeting indolent lymphoid malignancies. Its anticancer mechanisms include inhibiting DNA synthesis and inducing apoptosis, among others [1].