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ML337

Name: ML337
Brand: TargetMol
SKU: T23003
Price: 325 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T23003Cas No. 1443118-44-2

Alias ML 337

ML337 is a negative allosteric modulator of mGlu3 with an IC50 of 593 nM.

ML337

🥰Excellent

Purity: 99.83%

Catalog No. T23003Alias ML 337Cas No. 1443118-44-2

ML337 is a negative allosteric modulator of mGlu3 with an IC50 of 593 nM.

Pack Size	Price	Availability
1 mg	$30	In Stock
5 mg	$58	In Stock
10 mg	$98	In Stock
25 mg	$217	In Stock
50 mg	$325	In Stock
100 mg	Preferential	In Stock
1 mL x 10 mM (in DMSO)	$69	In Stock

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Batch Information

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Purity:99.83%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	ML337 is a negative allosteric modulator of mGlu3 with an IC50 of 593 nM.
Targets&IC50	mGluR3:593 nM (IC50)
Synonyms	ML 337

Chemical Properties

Molecular Weight	353.39
Formula	C₂₁H₂₀FNO₃
Cas No.	1443118-44-2
Smiles	COc1ccc(cc1)C#Cc1ccc(C(=O)N2CCC[C@@H](O)C2)c(F)c1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 31.8 mg/mL (89.99 mM), Sonication is recommended.

Ethanol: < 7.07 mg/mL, Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8297 mL	14.1487 mL	28.2973 mL	141.4867 mL
5 mM	0.5659 mL	2.8297 mL	5.6595 mL	28.2973 mL
10 mM	0.2830 mL	1.4149 mL	2.8297 mL	14.1487 mL
20 mM	0.1415 mL	0.7074 mL	1.4149 mL	7.0743 mL
50 mM	0.0566 mL	0.2830 mL	0.5659 mL	2.8297 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc