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TC-N 1752

🥰Excellent
Catalog No. T23439Cas No. 1211866-85-1

TC-N 1752 is an orally active inhibitor of Nav1.7 channel with IC50 of 0.17 μM. TC-N 1752 shows analgesic activities.

TC-N 1752

TC-N 1752

🥰Excellent
Purity: 99.71%
Catalog No. T23439Cas No. 1211866-85-1
TC-N 1752 is an orally active inhibitor of Nav1.7 channel with IC50 of 0.17 μM. TC-N 1752 shows analgesic activities.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$30In StockIn Stock
5 mg$73In StockIn Stock
10 mg$119In StockIn Stock
25 mg$273In StockIn Stock
50 mg$403In StockIn Stock
100 mg$573In StockIn Stock
200 mg$779In StockIn Stock
1 mL x 10 mM (in DMSO)$80In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.71%
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Product Introduction

Bioactivity
Description
TC-N 1752 is an orally active inhibitor of Nav1.7 channel with IC50 of 0.17 μM. TC-N 1752 shows analgesic activities.
Targets&IC50
Nav1.3 (human):0.3 μM (IC50), Nav1.7 (human):0.17 μM (IC50), Nav1.5 (human):1.1 μM (IC50), Nav1.8 (human):0.1 μM (IC50), Nav1.4 (human):0.4 μM (IC50)
In vitro
TC-N 1752 exhibits IC50s of 0.2, 0.1, 1.6, 0.5 and 1.4 μM for hNav1.7, hNav1.8, hNav1.9, rNav1.9, and mNav1.9[1]. TC-N 1752 state-dependently inhibits Nav1.7 channel on channels that are 20% inactivated(IC50 = 170 nM) and on fully noninactivated channels(IC50 = 3.6 μM)[1].
In vivo
TC-N 1752 (5 mg/ml; i.v.) attenuates Freund's adjuvant-induced sensitization of C fiber nociceptors[2]. TC-N 1752 (3-30 mg/kg; orally) exhibits analgesic effects in a dose-dependent manner in a formalin model and reduces thermal hyperalgesia produced by inflammation[3].
Chemical Properties
Molecular Weight516.52
FormulaC25H27F3N6O3
Cas No.1211866-85-1
SmilesCC(=O)Nc1cccc(Nc2ncnc(n2)N2CCC(CC2)OCc2ccc(OC(F)(F)F)cc2)c1C
Relative Density.1.37 g/cm3 (Predicted)
Storage & Solubility Information
Storagekeep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 112.5 mg/mL (217.8 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.9360 mL9.6802 mL19.3603 mL96.8017 mL
5 mM0.3872 mL1.9360 mL3.8721 mL19.3603 mL
10 mM0.1936 mL0.9680 mL1.9360 mL9.6802 mL
20 mM0.0968 mL0.4840 mL0.9680 mL4.8401 mL
50 mM0.0387 mL0.1936 mL0.3872 mL1.9360 mL
100 mM0.0194 mL0.0968 mL0.1936 mL0.9680 mL

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Keywords

TC-N-1752TC-N1752TC-N 1752TCN 1752TC N 1752SodiumChannelSodium ChannelNav1.7 channel
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