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Zagociguat

Name: Zagociguat
Brand: TargetMol
SKU: T39673
Price: 100 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T39673Cas No. 2201048-82-8

Alias IW-6463, IW6463, CY-6463, CY6463

Zagociguat (CY6463) is a soluble guanylate cyclase stimulator with central nervous system penetrance, enhancing nitric oxide (NO) signaling and used in the study of neurological diseases.

Zagociguat

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Purity: 99.37%

Catalog No. T39673Alias IW-6463, IW6463, CY-6463, CY6463Cas No. 2201048-82-8

Zagociguat (CY6463) is a soluble guanylate cyclase stimulator with central nervous system penetrance, enhancing nitric oxide (NO) signaling and used in the study of neurological diseases.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$100	-	In Stock
5 mg	$247	-	In Stock
10 mg	$396	-	In Stock
25 mg	$787	-	In Stock
50 mg	$1,180	-	In Stock
100 mg	$1,650	-	In Stock
200 mg	$2,220	-	In Stock
1 mL x 10 mM (in DMSO)	$272	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.37%

Appearance:Solid

Color:Yellow

Resource Download

COA FNMR HPLC HNMR

Product Introduction

Bioactivity

Description	Zagociguat (CY6463) is a soluble guanylate cyclase stimulator with central nervous system penetrance, enhancing nitric oxide (NO) signaling and used in the study of neurological diseases.
Targets&IC50	CREB:25.7 nM (EC50)
In vitro	CREB phosphorylation was stimulated by Zagociguat in a concentration-dependent manner in primary rat neurons with EC50 of 25.7 nM. [1]
In vivo	When Zagociguat was administered to rats at 10 mg/kg, cGMP levels were higher in cerebrospinal fluid compared to 3 mg/kg, suggesting that Zagociguat is a CNS permeable compound capable of triggering an increase in cGMP in the CNS. Zagociguat (10 mg/kg) decreased plasma inflammatory markers and increased BDNF in obese mice. [1]
Synonyms	IW-6463, IW6463, CY-6463, CY6463

Chemical Properties

Molecular Weight	362.28
Formula	C₁₆H₁₀F₄N₆
Cas No.	2201048-82-8
Smiles	FC=1C=CC=CC1CC2=NC(=CN3C=CN=C23)C4=NN=C(N4)C(F)(F)F

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 200 mg/mL (552.06 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7603 mL	13.8015 mL	27.6030 mL	138.0148 mL
5 mM	0.5521 mL	2.7603 mL	5.5206 mL	27.6030 mL
10 mM	0.2760 mL	1.3801 mL	2.7603 mL	13.8015 mL
20 mM	0.1380 mL	0.6901 mL	1.3801 mL	6.9007 mL
50 mM	0.0552 mL	0.2760 mL	0.5521 mL	2.7603 mL
100 mM	0.0276 mL	0.1380 mL	0.2760 mL	1.3801 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc