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Zagociguat

Name: Zagociguat
Brand: TargetMol
SKU: T39673
Price: 100 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T39673Cas No. 2201048-82-8

Alias IW-6463, IW6463, CY-6463, CY6463

Zagociguat (CY6463) is a soluble guanylate cyclase stimulator with central nervous system penetrance, enhancing nitric oxide (NO) signaling and used in the study of neurological diseases.

Zagociguat

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Purity: 99.37%

Catalog No. T39673Alias IW-6463, IW6463, CY-6463, CY6463Cas No. 2201048-82-8

Zagociguat (CY6463) is a soluble guanylate cyclase stimulator with central nervous system penetrance, enhancing nitric oxide (NO) signaling and used in the study of neurological diseases.

Pack Size	Price	Availability
1 mg	$100	In Stock
5 mg	$247	In Stock
10 mg	$396	In Stock
25 mg	$787	In Stock
50 mg	$1,180	In Stock
100 mg	$1,650	In Stock
200 mg	$2,220	In Stock
1 mL x 10 mM (in DMSO)	$272	In Stock

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Purity:99.37%

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COA FNMR HPLC HNMR

Product Introduction

Bioactivity

Description	Zagociguat (CY6463) is a soluble guanylate cyclase stimulator with central nervous system penetrance, enhancing nitric oxide (NO) signaling and used in the study of neurological diseases.
Targets&IC50	CREB:25.7 nM (EC50)
In vitro	CREB phosphorylation was stimulated by Zagociguat in a concentration-dependent manner in primary rat neurons with EC50 of 25.7 nM. [1]
In vivo	When Zagociguat was administered to rats at 10 mg/kg, cGMP levels were higher in cerebrospinal fluid compared to 3 mg/kg, suggesting that Zagociguat is a CNS permeable compound capable of triggering an increase in cGMP in the CNS. Zagociguat (10 mg/kg) decreased plasma inflammatory markers and increased BDNF in obese mice. [1]
Synonyms	IW-6463, IW6463, CY-6463, CY6463

Chemical Properties

Molecular Weight	362.28
Formula	C₁₆H₁₀F₄N₆
Cas No.	2201048-82-8
Smiles	FC=1C=CC=CC1CC2=NC(=CN3C=CN=C23)C4=NN=C(N4)C(F)(F)F
Color	Yellow
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 200.00 mg/mL (552.06 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7603 mL	13.8015 mL	27.6030 mL	138.0148 mL
5 mM	0.5521 mL	2.7603 mL	5.5206 mL	27.6030 mL
10 mM	0.2760 mL	1.3801 mL	2.7603 mL	13.8015 mL
20 mM	0.1380 mL	0.6901 mL	1.3801 mL	6.9007 mL
50 mM	0.0552 mL	0.2760 mL	0.5521 mL	2.7603 mL
100 mM	0.0276 mL	0.1380 mL	0.2760 mL	1.3801 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

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