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ZM 226600

Name: ZM 226600
Brand: TargetMol
SKU: T23563
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T23563Cas No. 147695-92-9

ZM 226600 is an ATP-sensitive potassium channel opener with an EC50 value of 500 nM. ZM226600 has an inhibitory effect on spontaneous bladder activity.

ZM 226600

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Purity: 99.87%

Catalog No. T23563Cas No. 147695-92-9

ZM 226600 is an ATP-sensitive potassium channel opener with an EC50 value of 500 nM. ZM226600 has an inhibitory effect on spontaneous bladder activity.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$30	In Stock	In Stock
5 mg	$46	In Stock	In Stock
10 mg	$73	In Stock	In Stock
25 mg	$148	In Stock	In Stock
50 mg	$238	In Stock	In Stock
100 mg	$353	In Stock	In Stock
200 mg	$493	-	In Stock
1 mL x 10 mM (in DMSO)	$50	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.87%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	ZM 226600 is an ATP-sensitive potassium channel opener with an EC50 value of 500 nM. ZM226600 has an inhibitory effect on spontaneous bladder activity.
Targets&IC50	K+ channel:500 nM(EC50)
In vitro	ZM226600 (1 μM, 30 min) inhibited spontaneous bladder activity. [1]
In vivo	ZM226600 (10-1000 nmol/kg, i.v.) did not significantly affect the heart rate in anesthetized rats.[1]

Chemical Properties

Molecular Weight	373.35
Formula	C₁₆H₁₄F₃NO₄S
Cas No.	147695-92-9
Smiles	S(=O)(=O)(C1=CC=C(NC(C(C(F)(F)F)(C)O)=O)C=C1)C2=CC=CC=C2
Relative Density.	1.448g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 90 mg/mL (241.06 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6785 mL	13.3923 mL	26.7845 mL	133.9226 mL
5 mM	0.5357 mL	2.6785 mL	5.3569 mL	26.7845 mL
10 mM	0.2678 mL	1.3392 mL	2.6785 mL	13.3923 mL
20 mM	0.1339 mL	0.6696 mL	1.3392 mL	6.6961 mL
50 mM	0.0536 mL	0.2678 mL	0.5357 mL	2.6785 mL
100 mM	0.0268 mL	0.1339 mL	0.2678 mL	1.3392 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc