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ZM 226600

Name: ZM 226600
Brand: TargetMol
SKU: T23563
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T23563Cas No. 147695-92-9

ZM 226600 is an ATP-sensitive potassium channel opener with an EC50 value of 500 nM. ZM226600 has an inhibitory effect on spontaneous bladder activity.

ZM 226600

🥰Excellent

Catalog No. T23563Cas No. 147695-92-9

ZM 226600 is an ATP-sensitive potassium channel opener with an EC50 value of 500 nM. ZM226600 has an inhibitory effect on spontaneous bladder activity.

Pack Size	Price	Availability
2 mg	$30	In Stock
5 mg	$46	In Stock
10 mg	$73	In Stock
25 mg	$148	In Stock
50 mg	$238	In Stock
100 mg	$353	In Stock
200 mg	$493	In Stock
1 mL x 10 mM (in DMSO)	$50	In Stock

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Batch Information

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Purity:>99.99%

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	ZM 226600 is an ATP-sensitive potassium channel opener with an EC50 value of 500 nM. ZM226600 has an inhibitory effect on spontaneous bladder activity.
Targets&IC50	K+ channel:500 nM(EC50)
In vitro	ZM226600 (1 μM, 30 min) inhibited spontaneous bladder activity. [1]
In vivo	ZM226600 (10-1000 nmol/kg, i.v.) did not significantly affect the heart rate in anesthetized rats.[1]

Chemical Properties

Molecular Weight	373.35
Formula	C₁₆H₁₄F₃NO₄S
Cas No.	147695-92-9
Smiles	S(=O)(=O)(C1=CC=C(NC(C(C(F)(F)F)(C)O)=O)C=C1)C2=CC=CC=C2
Relative Density.	1.448g/cm3
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 90 mg/mL (241.06 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6785 mL	13.3923 mL	26.7845 mL	133.9226 mL
5 mM	0.5357 mL	2.6785 mL	5.3569 mL	26.7845 mL
10 mM	0.2678 mL	1.3392 mL	2.6785 mL	13.3923 mL
20 mM	0.1339 mL	0.6696 mL	1.3392 mL	6.6961 mL
50 mM	0.0536 mL	0.2678 mL	0.5357 mL	2.6785 mL
100 mM	0.0268 mL	0.1339 mL	0.2678 mL	1.3392 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc