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AM12
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Catalog No. T13546Cas No. 2387510-84-9
AM12 inhibits lanthanide-evoked TRPC5 activity (IC50: 0.28 μM).
AM12
😃Good
Catalog No. T13546Cas No. 2387510-84-9
AM12 inhibits lanthanide-evoked TRPC5 activity (IC50: 0.28 μM).
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 10 mg | $4,780 | 35 days | 35 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Chemical Properties
| Description | AM12 inhibits lanthanide-evoked TRPC5 activity (IC50: 0.28 μM). |
| Targets&IC50 | TRPC5:0.28 μM |
| In vitro | AM12 inhibits TRPC5 and TRPC4 channel activities evoked by the agonist (-)-Englerin A via a site accessible from the extracellular face of the membrane, acting directly on either the channel or a closely associated site. It also inhibits Ca2+ entry evoked by Gd3+, with an IC50 of 0.28 μM, demonstrating slightly higher potency than the natural product Galangin. |
| Molecular Weight | 349.13 |
| Formula | C15H9BrO5 |
| Cas No. | 2387510-84-9 |
| Relative Density. | 1.864 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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