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GSK 3008348 hydrochloride
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Catalog No. T15583Cas No. 1629249-40-6
Alias GSK-3008348 hydrochloride, GSK3008348 hydrochloride
GSK 3008348 hydrochloride is an αvβ6 integrin inhibitor used to confirm idiopathic pulmonary fibrosis.
GSK 3008348 hydrochloride
😃Good
Purity: 99.54%
Catalog No. T15583Alias GSK-3008348 hydrochloride, GSK3008348 hydrochlorideCas No. 1629249-40-6
GSK 3008348 hydrochloride is an αvβ6 integrin inhibitor used to confirm idiopathic pulmonary fibrosis.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $89 | Inquiry | Inquiry | |
| 5 mg | $247 | Inquiry | Inquiry | |
| 10 mg | $347 | Inquiry | Inquiry | |
| 25 mg | $579 | Inquiry | Inquiry | |
| 50 mg | $828 | Inquiry | Inquiry | |
| 100 mg | $1,160 | Inquiry | Inquiry |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.54%
Appearance:Solid
Color:Yellow
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | GSK 3008348 hydrochloride is an αvβ6 integrin inhibitor used to confirm idiopathic pulmonary fibrosis. |
| Targets&IC50 | ανβ5 integrin:6.9 (pIC50), αvβ3 integrin:6 (pIC50), ανβ8 integrin:7.7 (pIC50), αvβ6 integrin:8.4 (pIC50) |
| In vitro | b>METHODS: GSK 3008348 hydrochloride was subjected to fluorescence polarization assay. RESULTS: The affinity of GSK 3008348 hydrochloride for human-6 protein was 8.1 (pIC50), while its affinity in the cell adhesion assay was: 6 (pIC50) for ανβ3; 6.9 (pIC50) for ανβ5; 8.4 (pIC50) for αvβ6; and 7.7 (pIC50) for ανβ8. [1] |
| Synonyms | GSK-3008348 hydrochloride, GSK3008348 hydrochloride |
| Formula | C29H37N5O2 xHCl |
| Cas No. | 1629249-40-6 |
| Smiles | CC=1N(C2=CC([C@@H](CN3C[C@H](CCC=4NC=5C(=CC4)CCCN5)CC3)CC(O)=O)=CC=C2)N=C(C)C1.Cl xHCl |
| Relative Density. | no data available |
| Storage | store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO: 11.66 mg/mL, Sonication and heating are recommended. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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