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Results for "

α2a

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    51
    TargetMol | Inhibitors_Agonists
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    2
    TargetMol | Peptide_Products
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Fiduxosin
ABT 980, A 185980.1
T11286208993-54-8In house
Fiduxosin is a selective and potent α1-adrenoceptor antagonist with inhibitory effects on α1a-adrenoceptor, α1b-adrenoceptor and α1d-adrenoceptor, with Ki values of 0.160 nM, 24.9 nM and 0.920 nM, respectively. Fiduxosin can be used for the treatment of benign prostatic hyperplasia.
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8-10 weeks
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Lusaperidone
R107474
T11894214548-46-6In house
Lusaperidone (R107474) is a potent α2-adrenergic receptor antagonist, a potential radioligand for the α (2)-adrenergic receptor, with inhibitory effects on α2A and α2C, with Ki values of 0.13 and 0.15 nM, respectively.
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6-8 weeks
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Benzquinamide
P2647, BZQ, Benzoquinamide
T1234363-12-7In house
Benzquinamide (P2647), an antiemetic agent with anticancer activity, inhibits p-glycoprotein-mediated drug efflux and potentiates the cytotoxicity of anticancer drugs in multidrug-resistant cells.The Ki values of Benzquinamide for α2A, α2B, and α2C adrenergic receptor (α2-AR) were 1,365, 691, and 545 nM, respectively. 545 nM, respectively.
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3-6 months
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OPC-28326
T13804167626-17-7In house
OPC-28326 is a specific an α2-adrenergic receptor antagonist and acts as a peripheral vasodilator. OPC-28326 inhibits α2A-, α2B- and α2C-adrenoceptors with Ki of 2040, 285, and 55 nM, respectively.
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8-10weeks
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TargetMol | Inhibitor Sale
jp1302
T2288280259-18-3In house
JP1302 is a selective α2C adrenoceptor antagonist with a Kb value of 16 nM and a Ki of 28 nM for human α2C receptors.JP1302 has antidepressant activity, disrupts the FACT complex and degrades histone H1.JP1302 has been used in the study of neuropsychiatric disorders, acute renal failure, and renal injury.
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6-8 weeks
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Fipamezole
JP-1730, JP1730, JP 1730, BVF-025
T24064150586-58-6In house
Fipamezole is a potent alpha2 adrenergic receptor antagonist that may be useful for studying autonomic dysfunction in Parkinson's disease.
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6-8weeks
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IDX184
IDX-184, IDX 184
T275861036915-08-8In house
IDX184 is a potent, orally active, targeted HCV polymerase inhibitor and nucleoside polymerase.IDX184 effectively inhibits HCV polymerase (IC50=0.31 μM, Ki=52.3 nM). IDX184 is a liver-targeted nucleotide prodrug with anti-HCV activity that inhibits HCV NS5B polymerase and can be used in combination with pegylated interferon-α2a and ribavirin for the primary treatment of chronic hepatitis C. It has been shown to inhibit HCV polymerase and nucleoside polymerase.
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10-14 weeks
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Nemazoline Free Base
T71012130759-56-7In house
Nemazoline Free Base acts as an α1-adrenergic agonist and an α2-adrenergic antagonist, and may be used in the treatment of trace amine-associated receptor-related disorders.
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6-8 weeks
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Ziprasidone hydrochloride monohydrate
CP 88059
T0031138982-67-9
Ziprasidone hydrochloride monohydrate (CP 88059) is a united 5-HT (serotonin) and dopamine receptor antagonist which shows potent effects of the antipsychotic activity.
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Ziprasidone hydrochloride
Ziprasidone HCl, CP-88059 hydrochloride
T0031L122883-93-6
Ziprasidone hydrochloride (CP-88059 hydrochloride) is a united 5-HT (serotonin) and dopamine receptor antagonist which shows potent effects of antipsychotic activity.
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Xylometazoline hydrochloride
Xylometazoline HCl
T00421218-35-5
Xylometazoline hydrochloride (Xylometazoline HCl) is an α-adrenoceptor agonist usually used as nasal decongestant.
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Guanfacine hydrochloride
Intuniv hcl, Tenex hcl
T215029110-48-3
Guanfacine hydrochloride (Intuniv) is a centrally acting antihypertensive agent with specificity towards ADRENERGIC ALPHA-2 RECEPTORS.
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TargetMol | Inhibitor Sale
Piribedil
EU-4200, Trivastan, ET-495, Trivastal
T32783605-01-4
Piribedil (Trivastan) is a dopamine D2 agonist, used in the treatment of Parkinson's disease.
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Guanabenz Acetate
Wy8678 acetate, BR-750, Wytensin
T652223256-50-0
Guanabenz Acetate (Wytensin) is a specific agonist of adrenergic receptor. The pEC50 for α2a-adrenergic receptor, α2b-adrenergic receptor and α2c-adrenergic receptor is 8.25, 7.01 and ~5, respectively.
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Norepinephrine
Nor-Epirenan, L-Noradrenaline, Levophed, Levonoradrenaline, Levonor, Arterenol, Aktamin
T704451-41-2
Norepinephrine (Levophed) can stimulate apoptosis in adult rat ventricular myocytes by activation of the β-adrenergic pathway. It can up-regulate the expression of vascular endothelial growth factor, matrix metalloproteinase (MMP)-2, and MMP-9 in nasopharyngeal carcinoma tumour cells.
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Benzylamine hydrochloride
TN34973287-99-8
Benzylamine hydrochloride, made of benzylamine and hydrochloric acid, is used to treat motion sickness and ascariasis, with antiemesis properties.
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Ecopipam
UNII-0X748O646K, Sch-39166, Sch 39166
T31602112108-01-7
Ecopipam (UNII-0X748O646K) is a potent, selective, and orally active antagonist of dopamine D1 D5 receptors, with Kis of 1.2 nM and 2.0 nM, respectively. Ecopipam demonstrates more than 40-fold selectivity over D2, D4, 5-HT, and α2a receptors (Ki=0.98, 5.52, 0.08, and 0.73 μM, respectively). It is used in research on schizophrenia and obesity.
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6-8 weeks
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AGN 192836
T10264171102-29-7In house
AGN 192836 is a potent and selective α2 adrenergic agonist with EC50s of 8.7 nM, 41 nM, and 6.6 nM for the α2A, α2B, and α2C receptors, respectively.
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8-10 weeks
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Ziprasidone
Geodon, Zeldox, CP-88059
T0031L2146939-27-7
Ziprasidone (Geodon) is a united 5-HT (serotonin) and dopamine receptor antagonist which shows potent effects of antipsychotic activity.
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Lurasidone hydrochloride
Lurasidone HCl, SM-13496 Hydrochloride
T1735367514-88-3
Lurasidone hydrochloride (Lurasidone HCl) is a thiazole derivative and atypical antipsychotic agent that functions as a dopamine D2 receptor antagonist; serotonin 5-HT2 receptor antagonist, serotonin 5-HT7 receptor antagonist, an antagonist of the adrenergic α2A and α2C receptors, as well as a partial serotonin 5-HT1A receptor agonist. It is used in the treatment of schizophrenia and bipolar disorder.
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Brimonidine Tartrate
UK 14304 (tartrate), AGN190342 (tartrate), UK14304 tartrate, AGN190342 tartrate
T642270359-46-5
Brimonidine Tartrate (AGN190342 tartrate) is a quinoxaline derivative and adrenergic α-2 receptor agonist (EC50: 0.45 nM) that is used to manage intraocular pressure associated with open-angle glaucoma or ocular hypertension.
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JP1302 dihydrochloride
T117261259314-65-2
JP1302 dihydrochloride is a selective, high affinity antagonist of the alpha2C-adrenoceptor (α2C-adrenoceptor), with a Ki (binding affinity) value of 28 nM and a Kb value (antagonist activity) of 16 nM.
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ARC 239 dihydrochloride
T2203355974-42-0
ARC 239 dihydrochloride is a selective α2B adrenoceptor antagonist with pKD values of 8.8, 6.7, and 6.4 at α2B, α2A, and α2D receptors respectively (pKD values are 8.8, 6.7, and 6.4 at α2B, α2A, and α2D receptors respectively).
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(S)-Terazosin
T12815109351-33-9
(S)-Terazosin is an active S-enantiomer of Terazosin and acts as a potent, high-affinity antagonist of α-adrenoceptors [α1a, α1b, and α1d-adrenoceptors] with Ki values of 3.91 nM, 0.79 nM, and 1.16 nM, respectively.
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6-8 weeks
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