fact

CBL0137 hydrochloride (Curaxin-137 hydrochloride) is an inhibitor of the histone chaperone FACT, which also activates p53 and inhibits NF-κB with EC50 values ​​of 0.37 and 0.47 μM, respectively. CBL0137 hydrochloride functionally inactivates the complex that promotes chromatin transcription (FACT), thereby driving effects on p53 and NF-κB and promoting cancer cell death, and when used in combination with cisplatin, CBL0137 hydrochloride has potent anticancer activity against SCLC.

Defactinib (VS-6063) is a second-generation inhibitor of FAK that inhibits FAK phosphorylation at the Tyr397 site. Defactinib has potential antitumor activity.

(Rel)-Factor B-IN-5 is a complement factor B inhibitor that can be used to study diseases associated with activation of the alternative complement pathway.

Surfactin is a potent cyclic lipopeptide biosurfactants that mediates flux of mono-and divalent cations, such as calcium, across lipid bilayer membranes, with anti-bacterial, anti-fungal, antimycoplasma and hemolytic effects.

Factor B-IN-5 is a complement factor B inhibitor, which can be used to study immune-related diseases.

NFAT Transcription Factor Regulator-1 is a synthesis inhibitor of IL-2 with an IC50 of 182 nM.

Euphorbia factor L25 is a useful organic compound for research related to life sciences and the catalog number is T125089.

Deoxy euphorbia factor L1 is a natural product found in the seeds of Euphorbia lathyris L

Surfactin C2 is a useful organic compound for research related to life sciences. The catalog number is T125603 and the CAS number is 171039-18-2.

Euphorbia factor L24 is a useful organic compound for research related to life sciences and the catalog number is T125685.

Euphorbia factor L22 is a useful organic compound for research related to life sciences and the catalog number is T125686.

Surfactin B1 is a useful organic compound for research related to life sciences. The catalog number is T125988 and the CAS number is 136109-79-0.

Euphorbia factor L9 is a useful organic compound for research related to life sciences and the catalog number is T126086.

Defactinib hydrochloride (PF 04554878 hydrochloride) is a novel inhibitor of FAK. Which inhibits FAK phosphorylation at the Tyr397 site in a time- and dose-dependent manner.

Complement factor D-IN-1 is a potent and selective small-molecule reversible Factor D inhibitor, with IC50 values of 0.006 μM in the FD Thioesterolytic Fluorescent Assay and 0.05 μM in the MAC Deposition Assay.

Spinosad Factor D is a naturally derived fermentation product. It is used as a pesticide against many different insects.

Defactinib analogue-1 (Compound 7) serves as a ligand for the target protein FAK, and is utilized in the synthesis of PROTAC FAK degrader 1.

Preimplantation Factor (PIF-1) exhibits potential activity against graft-versus-host disease (GVHD).

Factumycin is an antibiotic with broad-spectrum antibacterial activity, effective in vitro against both Gram-negative and Gram-positive bacteria. Additionally, Factumycin can serve as a growth promoter in animals.

Anti-virulence factor-IN-2 (compound C7) is an inhibitor targeting the virulence factor KpsM in Escherichia coli. KpsM facilitates the translocation of capsular polysaccharides to the cell surface, enabling KpsM-positive E. coli to evade phagocytosis by the scavenger receptor Marco on liver Kupffer cells, promoting bacterial dissemination. These bacteria can exacerbate ethanol-induced liver disease. Anti-virulence factor-IN-2 demonstrates anti-infective activity by inhibiting KpsM-dependent capsulation in a mouse model of ethanol-induced liver disease. This compound is applicable for alcoholic hepatitis research.

Factor B-IN-6 is an orally bioavailable inhibitor of Factor B. It exhibits significant inhibitory activity on the activation of the human serum alternative pathway. In model animals, Factor B-IN-6 can improve kidney lesions and function, reducing urinary protein levels. Factor B-IN-6 is applicable for kidney disease research.

eukaryotic translation elongation factor 1 alpha 1 (EEF1A1) encodes an isoform of the alpha subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This isoform (alpha 1) is expressed

Streptomyces A-Factor is a microbial hormone found in Streptomyces griseus. A-factor triggers streptomycin biosynthesis and cell differentiation by binding a repressor-type receptor protein (ArpA) and dissociating it from DNA.

Euphorbia factor L1 (Euphorbiasteroid) can reduce Bcl-2, PI3K, AKT, and mTOR protein and mRNA levels, and up-regulate caspase-9 and caspase-3 protein levels. It induces autophagy and has anti-cancer, anti-adipogenic, anti-osteoclastogenic, and multidrug-resistant regulatory effects.