43

RU-SKI 43 is a potent and selective hedgehog acyltransferase (Hhat) inhibitor with an IC50 of 850 nM. It exhibits anticancer activity and is a potential treatment for lung adenocarcinomas. RU-SKI 43 reduces Gli-1 activation through smoothening-independent non-canonical signaling and inhibits Akt and mTOR pathway activity.

INI-43, an inhibitor of Nuclear Import-43, shows a significant cytotoxic effect on various cervical and oesophageal cancer cell lines by targeting Kpnβ1 and interferes with the nuclear localization of Kpnβ1 and known Kpnβ1 cargoes, NFAT, NFκB, AP-1 and NF

BAY-43-9695 is a non-nucleoside compound with anti-human cytomegalovirus (HCMV) activity. It is the major metabolite of BAY-38-4766.

FGIN-1-43 is a potent and specific ligand for the mitochondrial DBI receptor.

Compound 872619-43-7, with CAS No. 872619-43-7, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound 872619-43-7 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

Pentosan Polysulfate Sodium is a potent and selective anti-HIV agent.with anti-inflammatory and pro-chondrogenic properties,and used for treatment of interstitial cystitis.

RU-SKI 43 Hydrochloride is a potent and selective inhibitor of Hedgehog acyltransferase (Hhat), with an IC50 value of 850 nM. RU-SKI 43 Hydrochloride has been reported to possess anticancer activity, making it a useful compound for investigating Hedgehog signaling in tumor biology.

SM-164 Hydrochloride is a cell-permeable Smac mimetic compound. SM-164 binds to XIAP protein containing both the BIR2 and BIR3 domains(IC50 value of 1.39 nM) and functions as an extremely potent antagonist of XIAP.

FPR Agonist 43 is a dual agonist of formyl peptide receptor 1 and formyl peptide receptor 2 (FPR2)/ALX.

Antimalarial agent 43 (compound 16c) is an antimalarial compound that exhibits an IC50 value of 0.0151 μM against the 3D7 strain.

E3 Ligase Ligand 43 is an E3 ubiquitin ligase ligand for ACBI3, used in the synthesis of PROTACs.

CDK2-IN-43 (Compound 3a) is a CDK2-cyclin E2 inhibitor with an IC50 value of 6.0 nM. It is applicable to cancer research.

BTK-IN-43 (compound 9) is an inhibitor of BTK with an IC50 value of 21.6 nM and is orally active.

MAO-B-IN-43 (4) is a potent inhibitor of hMAO-B and a mild inhibitor of GSK3β kinase, with Ki values for hMAO-A and hMAO-B of 0.044 μM and 0.004 μM, respectively. This compound is applicable in the study of neurodegenerative diseases.

SARS-CoV-2 Mpro-IN-43 (Compound 1) is an inhibitor of the coronavirus main protease (Mpro) with an IC50 of 72 μM. It exerts its antiviral effects by interacting non-covalently with the key residues at the Mpro active site. This compound exhibits moderate to low cytotoxicity with CC50 values of 13.24, 41.02, and 42.26 µM in HaCaT, HEK293T, and HepG2 cells, respectively. SARS-CoV-2 Mpro-IN-43 is applicable for SARS-CoV-2 research.

alpha-Gliadin (43-49) is a Gliadian sequence peptide. It could induce leukocyte migration inhibition but be blocked by naloxone.

Ro 43-5054 is a small molecular, noncyclic peptidomimetic inhibitor.

The amyloid β-protein is a 39- to 43-amino acid polypeptide that is the primary constituent of senile plaques and cerebrovascular deposits in Alzheimer's disease and Down's syndrome. Additionally it acts as an inhibitor of the ubiquitin-dependent protein degradation in vitro.

Antibacterial agent 43, is a potent antibacterial compound. It exhibits promising activity against bacterial infections and offers great potential for research purposes.

Protein E7(43-62) is a peptide derived from the E7 protein. The peptide spans the 43rd to 62nd amino acid residues and exhibits anti-tumor effects.

Gliadin p31-43, an undigested peptide derived from gliadin, prompts an innate immune response in the intestine and disrupts endocytic trafficking. Moreover, its utilization in celiac disease research has proven beneficial.

Antitumor agent-43 (Compound 4B) is a potent antitumor compound that induces cell cycle arrest at the G2 M phase, with an IC₅₀ of 0.5 μM for T-24 cells [1].

GG-43 is a potent inhibitor of LIN28. The IC50 value of GG-43 against human LIN28A is 4 μM [1].

Anticancer agent 43 is a potent anticancer agent that induces apoptosis through caspase 3, PARP1, and Bax protein-dependent pathways.Anticancer agent 43 induces DNA damage and can be used in the study of glioblastoma in rats.