43

RU-SKI 43 is a potent and selective hedgehog acyltransferase (Hhat) inhibitor with an IC50 of 850 nM. It exhibits anticancer activity and is a potential treatment for lung adenocarcinomas. RU-SKI 43 reduces Gli-1 activation through smoothening-independent non-canonical signaling and inhibits Akt and mTOR pathway activity.

INI-43, an inhibitor of Nuclear Import-43, shows a significant cytotoxic effect on various cervical and oesophageal cancer cell lines by targeting Kpnβ1 and interferes with the nuclear localization of Kpnβ1 and known Kpnβ1 cargoes, NFAT, NFκB, AP-1 and NF

BAY-43-9695 is a non-nucleoside compound with anti-human cytomegalovirus (HCMV) activity. It is the major metabolite of BAY-38-4766.

FGIN-1-43 is a potent and specific ligand for the mitochondrial DBI receptor.

Tubulin polymerization-IN-43 is an inhibitor of tubulin polymerisation.Tubulin polymerization-IN-43 has multiple effects, disrupting the cellular microtubule network by targeting the colchicine locus and promoting cell cycle arrest and apoptosis in leukaemia cells. Tubulin polymerisation-IN-43 has multiple effects, promoting leukaemia cell cycle arrest in G2 M phase and apoptosis by targeting Colchicine sites to disrupt the cellular microtubule network.

Pentosan Polysulfate Sodium is a potent and selective anti-HIV agent.with anti-inflammatory and pro-chondrogenic properties,and used for treatment of interstitial cystitis.

RU-SKI 43 hydrochloride is a potent and selective inhibitor of Hedgehog acyltransferase (Hhat) with an IC50 of 850 nM and exhibits anti-cancer activity.

SM-164 Hydrochloride is a cell-permeable Smac mimetic compound. SM-164 binds to XIAP protein containing both the BIR2 and BIR3 domains(IC50 value of 1.39 nM) and functions as an extremely potent antagonist of XIAP.

FPR Agonist 43 is a dual agonist of formyl peptide receptor 1 and formyl peptide receptor 2 (FPR2) ALX.

Antimalarial agent 43 (compound 16c) is an antimalarial compound that exhibits an IC50 value of 0.0151 μM against the 3D7 strain.

E3 Ligase Ligand 43 is an E3 ubiquitin ligase ligand for ACBI3, used in the synthesis of PROTACs.

alpha-Gliadin (43-49) is a Gliadian sequence peptide. It could induce leukocyte migration inhibition but be blocked by naloxone.

Ro 43-5054 is a small molecular, noncyclic peptidomimetic inhibitor.

Acid violet 43 is a violet dye.

The amyloid β-protein is a 39- to 43-amino acid polypeptide that is the primary constituent of senile plaques and cerebrovascular deposits in Alzheimer's disease and Down's syndrome. Additionally it acts as an inhibitor of the ubiquitin-dependent protein degradation in vitro.

Antibacterial agent 43, is a potent antibacterial compound. It exhibits promising activity against bacterial infections and offers great potential for research purposes.

Protein E7(43-62) is a peptide derived from the E7 protein. The peptide spans the 43rd to 62nd amino acid residues and exhibits anti-tumor effects.

Gliadin p31-43, an undigested peptide derived from gliadin, prompts an innate immune response in the intestine and disrupts endocytic trafficking. Moreover, its utilization in celiac disease research has proven beneficial.

Antitumor agent-43 (Compound 4B) is a potent antitumor compound that induces cell cycle arrest at the G2 M phase, with an IC₅₀ of 0.5 μM for T-24 cells [1].

GG-43 is a potent inhibitor of LIN28. The IC50 value of GG-43 against human LIN28A is 4 μM [1].

Anticancer agent 43 is a potent anticancer agent that induces apoptosis through caspase 3, PARP1, and Bax protein-dependent pathways.Anticancer agent 43 induces DNA damage and can be used in the study of glioblastoma in rats.

HDAC-IN-43 is a potent HDAC 1 3 6 inhibitor with IC50 values of 82 nM for HDAC 1, 45 nM for HDAC 3, and 24 nM for HDAC 6, and a weak PI3K mTOR inhibitor with IC50 values of 3.6 μM for PI3K and 3.7 μM for mTOR, exhibiting a broad-spectrum anti-proliferative effect.

HIV-1 inhibitor-43 is a potent inhibitor of HIV-1, acting on HIV-1 Y188L (EC50: 21.3 nM), K103N-Y181C (EC50: 6.2 nM), K103N (EC50 < 0.7 nM), and Y181C (EC50 < 0.7 nM). HIV-1 inhibitor-43 reduces the expression of HIV-1 RNA and protein p24.

Antifungal agent 43 is an antifungal agent that exhibits antifungal effect by inhibiting biofilm formation. antifungal agent 43 shows low toxicity to human cancer cell lines.