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Reticuline

Name: Reticuline
Brand: TargetMol
SKU: T4243
Rating: 4.5 (1 reviews)

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Catalog No. T4243Cas No. 485-19-8

Reticuline is an anti-inflammatory and antihypertensive natural product that reduces JAK2/STAT3 and NF-κB phosphorylation levels, inhibits TNF-α and IL-6 mRNA expression, thereby alleviating oedema in rats.

Reticuline

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Catalog No. T4243Cas No. 485-19-8

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg	Inquiry	Inquiry	Inquiry
5 mg	$1,390	Inquiry	Inquiry

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Appearance:Solid

Color:White

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COA

Product Introduction

Bioactivity

Description	Reticuline is an anti-inflammatory and antihypertensive natural product that reduces JAK2/STAT3 and NF-κB phosphorylation levels, inhibits TNF-α and IL-6 mRNA expression, thereby alleviating oedema in rats.
In vitro	In intact endothelium aortic rings, reticuline (3 μM-1.5 mM) concentration-dependently inhibited phenylephrine- and KCl (80 mM and 30 mM)-induced contractions, with IC50 values of 40±10, 240±40, and 300±40 μM, respectively [2]. After endothelium removal, the inhibitory effect of reticuline on phenylephrine-induced contraction was significantly attenuated, with an IC50 value of 250±70 μM [2]. In the presence of L-NAME (100 or 300 μM) or atropine (1 μM), the vasorelaxant effect of reticuline was also markedly reduced [2]. Reticuline further suppressed CaCl2-induced contraction and calcium transients triggered by the release of intracellular calcium stores sensitive to depolarizing agents such as phenylephrine, but did not affect caffeine-sensitive calcium stores [2].
In vivo	Reticuline (5, 10, and 20 mg/kg, intravenous injection) induced significant hypotensive responses in normotensive Wistar rats, accompanied by increased heart rate. After pretreatment with L-NAME or atropine, the hypotensive effect and tachycardia caused by reticuline were markedly attenuated or even completely abolished [2].

Chemical Properties

Molecular Weight	329.39
Formula	C₁₉H₂₃NO₄
Cas No.	485-19-8
Smiles	C([C@H]1C=2C(=CC(OC)=C(O)C2)CCN1C)C3=CC(O)=C(OC)C=C3
Relative Density.	1.217g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (242.87 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.3 mg/mL (10.02 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.0359 mL	15.1796 mL	30.3591 mL	151.7957 mL
5 mM	0.6072 mL	3.0359 mL	6.0718 mL	30.3591 mL
10 mM	0.3036 mL	1.5180 mL	3.0359 mL	15.1796 mL
20 mM	0.1518 mL	0.7590 mL	1.5180 mL	7.5898 mL
50 mM	0.0607 mL	0.3036 mL	0.6072 mL	3.0359 mL
100 mM	0.0304 mL	0.1518 mL	0.3036 mL	1.5180 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc