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Clothianidin

Name: Clothianidin
Brand: TargetMol
SKU: T21153
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T21153Cas No. 210880-92-5

Alias TI-435, TI435, TI 435, Celero

Clothianidin (TI 435), an insecticide, acts as an agonist of acetylcholine to stimulate nAChR, thereby activating post-synaptic acetylcholine receptors but not inhibiting AChE.

Clothianidin

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Purity: 99.87%

Catalog No. T21153Alias TI-435, TI435, TI 435, CeleroCas No. 210880-92-5

Clothianidin (TI 435), an insecticide, acts as an agonist of acetylcholine to stimulate nAChR, thereby activating post-synaptic acetylcholine receptors but not inhibiting AChE.

Pack Size	Price	USA Warehouse	Global Warehouse
100 mg	$39	In Stock	In Stock
200 mg	$56	In Stock	In Stock
500 mg	$92	-	In Stock
1 g	$135	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.87%

Color:White to Yellow

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COA HNMR LCMS

Product Introduction

Clothianidin AI Summary

Clothianidin displays diverse bioactivities and possesses significant potential as an acetylcholinesterase inhibitor and insecticide. In assays involving Aplysia AChBP expressed in HEK293S cells, it shows Ki values of 808 nM for [3H]ACE displacement and 574 nM for [3H]EPI displacement. Furthermore, Clothianidin acts as an agonist of glucocorticoid receptor signaling (89.1 nM potency), activates the p53 (28183.8 nM potency) and ARE signaling pathways (61130.6 nM potency), and inhibits Oryctolagus cuniculus AOX and Agaricus bisporus tyrosinase at IC50 concentrations, displaying some inhibition against xanthine oxidase with an IC50 of 1860000 nM. The compound exhibits high insecticidal efficacy, demonstrating 100% mortality in adult Aphis gossypii on cucumber cotyledons at 500 ppm after 72 hours and significant binding to [3H]IMI from nicotinic acetylcholine receptors in Drosophila melanogaster brain with a Ki of 4.0 nM. It also displaces [3H]IMI from nicotinic acetylcholine receptors in numerous insect species (IC50 values 1.8 nM to 9.2 nM), suggesting its use as a potent insecticide. It effectively inhibits first-instar larvae of Cheumatopsyche brevilineata (EC50 0.00444 µg/mL) and demonstrates insecticidal activity against Daphnia magna (EC50 >119 µg/mL). Clothianidin also shows strong insecticidal activity against both neonicotinoid-resistant and susceptible strains of Myzus persicae, with a high resistance index of 3013.0 and low LC50 of 0.3 ppm in susceptible strains. Additionally, it significantly reduces the body weight, honeydew excretion, and survival of imidacloprid-resistant Aphis gossypii. In beetle species, it achieves near-total mortality in Anomala orientalis (98.6%) and Maladera castanea (100%) after 30 days. Moreover, it effectively binds to the nAChR receptors in aphids, showing Ki values of 0.058 nM for [3H]-methyl-SFX displacement. Against Paralobesia viteana and Popillia japonica, the compound effectively reduces infestation and leaf damage using irrigation injection methods. In agricultural settings, it inhibits larval development of Contarinia nasturtii and emergence of Ceutorhynchus obstrictus adults in treated plants. Lastly, in Urochloa mutica (buffalo grass), it shows progressive drug uptake, reaching 6.48 µg/g of fresh weight after 3 days. Overall, Clothianidin's interdisciplinary activities, including its potential as an acetylcholinesterase inhibitor and versatile insecticidal properties, highlight it as a strong candidate for various applications in pest control and biochemical research..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Clothianidin (TI 435), an insecticide, acts as an agonist of acetylcholine to stimulate nAChR, thereby activating post-synaptic acetylcholine receptors but not inhibiting AChE.
Synonyms	TI-435, TI435, TI 435, Celero

Chemical Properties

Molecular Weight	249.68
Formula	C₆H₈ClN₅O₂S
Cas No.	210880-92-5
Smiles	C\N=C(\NCc1cnc(Cl)s1)N[N+]([O-])=O
Relative Density.	1.61

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 125 mg/mL (500.64 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (8.01 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.0051 mL	20.0256 mL	40.0513 mL	200.2563 mL
5 mM	0.8010 mL	4.0051 mL	8.0103 mL	40.0513 mL
10 mM	0.4005 mL	2.0026 mL	4.0051 mL	20.0256 mL
20 mM	0.2003 mL	1.0013 mL	2.0026 mL	10.0128 mL
50 mM	0.0801 mL	0.4005 mL	0.8010 mL	4.0051 mL
100 mM	0.0401 mL	0.2003 mL	0.4005 mL	2.0026 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc