a1

Adenosine A1 receptor activator T62 is an allosteric enhancer of the adenosine A1 receptor, producing antinociception in animal models of acute pain and reducing hypersensitivity in models of inflammatory and nerve-injury pain[1][2][3].

Bafilomycin A1 belongs to the macrolide class of antibiotics and is a V-ATPase inhibitor (IC50=0.44 nM) that is specific and reversible. Bafilomycin A1 is an inhibitor of the late phase of autophagy, blocking the fusion of autophagosomes with lysosomes. Bafilomycin A1 also induces apoptosis.

Enniatin A1, a cyclic hexadepsipeptide composed of alternating D-α-hydroxyisovaleric acids and N-methyl-L-amino acids isolated from Fusarium mycotoxins, exhibits anticarcinogenic effects through the induction of apoptosis and disruption of the ERK signaling pathway. It also inhibits ACAT in rat liver microsomes with an IC50 of 49 μM.

Mogroside I A1, a triterpenoid glycoside isolated from extracts of Luo Han Guo, exhibits antioxidant, antidiabetic, and anticancer activities.

Schidigera saponin A1 is an natural product extracted from the stems of Y. schidigera, which exhibited potent growth-inhibitory activities against certain food-deteriorating yeasts, film-forming yeasts, and dermatophytic yeasts and fungi.

Kapurimycin A1 is an antitumor antibiotic produced by Streptomyces.

Deltamycin A1 is a novel macrolide antibiotic.

Yl 704 A1 is a primary component of macrolide antibiotic YL-704 from Streptomyces platensis subsp. malvinus.

Hederacolchiside A1 (Raddeanoside R13) shows anti-leishmanial activity, it exhibits a strong antiproliferative activity on all stages of development of the parasite by altering membrane integrity and potential. Hederacolchiside A1 shows antiproliferation activities in three cancer cell lines with the IC50 value of 2.4 uM, it exhibits a preferential cytotoxicity on a pigmented melanoma cell line. It suppresses proliferation of tumor cells by inducing apoptosis through modulating PI3K/Akt/mTOR signaling pathway.

Timosaponin A1, a coprostane-type steroidal saponin, is found in Rhizoma Anemarrhenae.

Arizonin A1 is a biochemical.

Napyradiomycin A1is a fungal metabolite originally isolated fromC. rubraand has diverse biological activities.1,2It is active againstS. aureus,M. luteus,B. anthracis,C. bovis, andM. smegmatis(MICs = 1.56-12.5 μg/ml).1Napyradiomycin A1is an estrogen receptor antagonist (IC50= 4.2 μM in rat uterine homogenates).2It also inhibits mitochondrial NADH:ubiquinone oxidoreductase (complex I) and succinate:ubiquinone oxidoreductase (complex II) activities in bovine heart homogenates (IC50s = 20 and 9.7 μM, respectively).3 1.Shiomi, K., Iinuma, H., Hamada, M., et al.Novel antibiotics napyradiomycins. Production, isolation, physico-chemical properties and biological activityJ. Antibiot. (Tokyo)39(4)487-493(1986) 2.Hori, Y., Abe, Y., Shigematsu, N., et al.Napyradiomycins A and B1: Non-steroidal estrogen-receptor antagonists produced by a StreptomycesJ. Antibiot. (Tokyo)46(12)1890-1893(1993) 3.Yamamoto, K., Tashiro, E., Motohashi, K., et al.Napyradiomycin A1, an inhibitor of mitochondrial complexes I and IIJ. Antibiot. (Tokyo)65(4)211-214(2012)

Xanthoquinodin A1 is a fungal metabolite that has been found inHumicolaand has diverse biological activities.1,2It inhibitsE. tenellaschizont formation in BHK-21 cells with a minimum effective concentration (MEC) value of 0.02 μg/ml.1Xanthoquinodin A1 is active againstB. subtilis,M. luteus,S. aureus,A. laidlawii, andB. fragilisin a disc assay when used at a concentration of 1 mg/ml. It is also active againstB. cereus(MIC = 0.44 μM).2Xanthoquinodin A1 is cytotoxic to KB, MCF-7, and NCI H187 cancer cells. 1.Tabata, N., Suzumura, Y., Tomoda, H., et al.Xanthoquinodins, new anticoccidial agents produced by Humicola sp. Production, isolation and physico-chemical and biological propertiesJ. Antibiot. (Tokyo)46(5)749-755(1993) 2.Tantapakul, C., Promgool, T., Kanokmedhakul, K., et al.Bioactive xanthoquinodins and epipolythiodioxopiperazines from Chaetomium globosum 7s-1, an endophytic fungus isolated from Rhapis cochinchinensis (Lour.) MartNat. Prod. Res.34(4)494-502(2020)

16,16-dimethyl Prostaglandin A1 is a useful organic compound for research related to life sciences. The catalog number is T36040 and the CAS number is 41692-24-4.

Coumermycin A1, a JAK2 signal activator, inhibits DNA Gyrase, consequently impeding bacterial cell division.

Prostaglandin A1 (PGA1) was first isolated as a dehydration product of the PGE1 compounds found in human semen. 15-keto PGA1 is a metabolite of PGA1, produced by 15-hydroxy PG dehydrogenase. It can be produced from PGA1 in pig lung, trachea, aorta, and pulmonary artery tissue preparations. 15-keto PGA1, given at a concentration of 6 μM, causes vasoconstriction of rabbit lung that is comparable to that induced by angiotensin II.

Esperamicin A1, an exceedingly potent antitumor antibiotic, is derived from Actinomadura verrucosospora cultures. This compound plays a crucial role in antitumor research.

Epimedin A1 (Hexandraside F)(Hexandraside F) is a flavonoid extracted from Herba Epimedii which is one of commonly used Chinese medicines.

Jionoside A1 is isolated and purified from the roots of Rehmannia glutinosa. It displays dose-dependent immune-enhancement activity and possesses moderate neuroprotective activities on H2O2-treated SH-SY5Y cells.

Combretastatin A1 phosphate, a potent vascular disruptive agent, exhibits anti-angiogenic effects on tumors and holds potential for research on pancreatic neuroendocrine tumors.

Procyanidin A1 (Proanthocyanidin A1) has antiallergic effects, it inhibits degranulation downstream of protein kinase C activation or Ca2+; influx from an internal store in RBL-2H3 cells.

Mogroside IIA1 (Mogroside II-A1) is isolated from the fruits of Siraitia grosvenorii. Mogroside IIA1 is a a nonsugar sweetener and sweeter than sucrose. Mogroside IIA1 possesses antioxidant, antidiabetic and anticancer activities.

Wulignan A1 exhibits activity against leukemia P-388 in vitro; it also may have anti-influenza virus H1N1 and H1N1-TR (a Tamiflu drug resistant virus strain) activities.

Vineomycin A1 (OS-4742 A1) is an antibiotic effective against Gram-positive bacteria, identified in *Streptomyces matensis* subsp. vineus. It has also demonstrated antitumor activity in mice and holds potential for research in skin fibrosis.