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AMG-811
Catalog No. T9901A-1349 Copy Product Info
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AMG-811 is a fully human IgG1 kappa monoclonal antibody targeting the cytokine interleukin-17C (IL-17C). It binds with high affinity and specificity to IL-17C, blocking its interaction with the receptor complex (IL-17RA/IL-17RE) and thereby neutralizing its biological activity. This inhibition attenuates downstream pro-inflammatory signaling and cytokine production driven by IL-17C. It is primarily used to investigate the role of IL-17C in the pathogenesis of autoimmune diseases such as psoriasis and inflammatory bowel disease.
AMG-811
Copy Product Info😃Good
Catalog No. T9901A-1349
AMG-811 is a fully human IgG1 kappa monoclonal antibody targeting the cytokine interleukin-17C (IL-17C). It binds with high affinity and specificity to IL-17C, blocking its interaction with the receptor complex (IL-17RA/IL-17RE) and thereby neutralizing its biological activity. This inhibition attenuates downstream pro-inflammatory signaling and cytokine production driven by IL-17C. It is primarily used to investigate the role of IL-17C in the pathogenesis of autoimmune diseases such as psoriasis and inflammatory bowel disease.
AMG-811
Cas No. 1439393-01-7
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| Description | AMG-811 is a fully human IgG1 kappa monoclonal antibody targeting the cytokine interleukin-17C (IL-17C). It binds with high affinity and specificity to IL-17C, blocking its interaction with the receptor complex (IL-17RA/IL-17RE) and thereby neutralizing its biological activity. This inhibition attenuates downstream pro-inflammatory signaling and cytokine production driven by IL-17C. It is primarily used to investigate the role of IL-17C in the pathogenesis of autoimmune diseases such as psoriasis and inflammatory bowel disease. |
| Reactivity | Human |
| Application | FACS Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Uniprot ID | |
| Target | IFNg |
| Cas No. | 1439393-01-7 |
| Isotype | IgG1 |
| Storage | store at low temperature | store at -20°C | Shipping with blue ice/Shipping at ambient temperature. |
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