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BMS-981164

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Catalog No. T9901A-1097 Copy Product Info
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BMS-981164 is a humanized antibody targeting interleukin-31 (IL-31) that can be used in the study of atopic dermatitis.

BMS-981164

Pack SizePriceUSA StockGlobal StockQuantity
1 mg$564InquiryInquiry
5 mgInquiryInquiryInquiry
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction

Bioactivity
Description
BMS-981164 is a humanized antibody targeting interleukin-31 (IL-31) that can be used in the study of atopic dermatitis.
In vitro
BMS-981164 binds IL-4Rα and IL-31 with high affinity. Its tetravalent structure enables sub-nanomolar (nM) inhibition of IL-4/IL-13-mediated STAT6 phosphorylation and IL-31-induced STAT3 activation, effectively suppressing both inflammatory and pruritogenic signaling [1].
In vivo
In non-human primate models, BMS-981164 dose-dependently suppresses skin inflammation and scratching behavior. The antibody effectively targets inflamed tissues, providing sustained neutralization of Th2 inflammation and pruritus [1].
Reactivity
Human
Application
FACS
Functional assay
Antibody Type
Monoclonal
FormulationSupplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition.
Endotoxin<1.0 EU/mg
Related Conjugates and Formulations
Conjucates
Unconjugated
Antigen Details
Uniprot ID
TargetIL-31
Antibody Information
IsotypeIgG4SP-opti
Storage & Solubility Information
StorageStore at low temperature Store at -20°C Shipping with blue ice/Shipping at ambient temperature.

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Related Tags: BMS-981164 in vivo | BMS-981164 in vitro