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BMS-981164
Catalog No. T9901A-1097 Copy Product Info
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BMS-981164 is a humanized antibody targeting interleukin-31 (IL-31) that can be used in the study of atopic dermatitis.
BMS-981164
Copy Product Info🥰Excellent
Catalog No. T9901A-1097
BMS-981164 is a humanized antibody targeting interleukin-31 (IL-31) that can be used in the study of atopic dermatitis.
BMS-981164
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $564 | Inquiry | Inquiry | |
| 5 mg | Inquiry | Inquiry | Inquiry |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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| Description | BMS-981164 is a humanized antibody targeting interleukin-31 (IL-31) that can be used in the study of atopic dermatitis. |
| In vitro | BMS-981164 binds IL-4Rα and IL-31 with high affinity. Its tetravalent structure enables sub-nanomolar (nM) inhibition of IL-4/IL-13-mediated STAT6 phosphorylation and IL-31-induced STAT3 activation, effectively suppressing both inflammatory and pruritogenic signaling [1]. |
| In vivo | In non-human primate models, BMS-981164 dose-dependently suppresses skin inflammation and scratching behavior. The antibody effectively targets inflamed tissues, providing sustained neutralization of Th2 inflammation and pruritus [1]. |
| Reactivity | Human |
| Application | FACS Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Uniprot ID | |
| Target | IL-31 |
| Isotype | IgG4SP-opti |
| Storage | Store at -20°C Shipping with blue ice/Shipping at ambient temperature. |
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