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GSK-933776 represents a highly specialized humanized monoclonal antibody specifically engineered to target the amino-terminal region of the human amyloid-beta peptide with exceptional binding affinity and selectivity, effectively facilitating the measurable neutralization of neurotoxic aggregates across various preclinical experimental models to evaluate the modulation of protein clearance and the restoration of complement homeostasis during strictly monitored laboratory observation periods and functional enzymatic assays to ensure high experimental sensitivity and accuracy.

| Description | GSK-933776 represents a highly specialized humanized monoclonal antibody specifically engineered to target the amino-terminal region of the human amyloid-beta peptide with exceptional binding affinity and selectivity, effectively facilitating the measurable neutralization of neurotoxic aggregates across various preclinical experimental models to evaluate the modulation of protein clearance and the restoration of complement homeostasis during strictly monitored laboratory observation periods and functional enzymatic assays to ensure high experimental sensitivity and accuracy. |
| In vitro | In biochemical assays using Amyloid beta complexes, GSK-933776 restored the bioactivity of Complement Factor I and regulated complement system activation [1]. |
| In vivo | In human models of age-related macular degeneration, systemic administration of GSK-933776 modulated complement deposition and restored complement balance [1]. |
| Reactivity | Human |
| Application | FACS Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Uniprot ID | |
| Target | Amyloid Beta/Aβ |
| Isotype | IgG1 |
| Storage | store at low temperature | store at -20°C | Shipping with blue ice/Shipping at ambient temperature. |
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