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GSK-933776

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Catalog No. T9901A-1248

GSK-933776 represents a highly specialized humanized monoclonal antibody specifically engineered to target the amino-terminal region of the human amyloid-beta peptide with exceptional binding affinity and selectivity, effectively facilitating the measurable neutralization of neurotoxic aggregates across various preclinical experimental models to evaluate the modulation of protein clearance and the restoration of complement homeostasis during strictly monitored laboratory observation periods and functional enzymatic assays to ensure high experimental sensitivity and accuracy.

GSK-933776

GSK-933776

Copy Product Info
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Catalog No. T9901A-1248
GSK-933776 represents a highly specialized humanized monoclonal antibody specifically engineered to target the amino-terminal region of the human amyloid-beta peptide with exceptional binding affinity and selectivity, effectively facilitating the measurable neutralization of neurotoxic aggregates across various preclinical experimental models to evaluate the modulation of protein clearance and the restoration of complement homeostasis during strictly monitored laboratory observation periods and functional enzymatic assays to ensure high experimental sensitivity and accuracy.
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Product Introduction

Bioactivity
Description
GSK-933776 represents a highly specialized humanized monoclonal antibody specifically engineered to target the amino-terminal region of the human amyloid-beta peptide with exceptional binding affinity and selectivity, effectively facilitating the measurable neutralization of neurotoxic aggregates across various preclinical experimental models to evaluate the modulation of protein clearance and the restoration of complement homeostasis during strictly monitored laboratory observation periods and functional enzymatic assays to ensure high experimental sensitivity and accuracy.
In vitro
In biochemical assays using Amyloid beta complexes, GSK-933776 restored the bioactivity of Complement Factor I and regulated complement system activation [1].
In vivo
In human models of age-related macular degeneration, systemic administration of GSK-933776 modulated complement deposition and restored complement balance [1].
Reactivity
Human
Application
FACS
Functional assay
Antibody Type
Monoclonal
FormulationSupplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition.
Endotoxin<1.0 EU/mg
Related Conjugates and Formulations
Conjucates
Unconjugated
Antigen Details
Uniprot ID
TargetAmyloid Beta/Aβ
Chemical Properties
Antibody Information
IsotypeIgG1
Storage & Solubility Information
Storagestore at low temperature | store at -20°C | Shipping with blue ice/Shipping at ambient temperature.

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