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AM-1638

Name: AM-1638
Brand: TargetMol
SKU: T14200
Rating: 4.5 (1 reviews)

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Catalog No. T14200Cas No. 1142214-62-7

Alias AM1638

AM-1638 is an orally active GPR40/FFA1 agonist, useful for studying type II diabetes.

AM-1638

😃Good

Catalog No. T14200Alias AM1638Cas No. 1142214-62-7

AM-1638 is an orally active GPR40/FFA1 agonist, useful for studying type II diabetes.

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$3,115	4-6 weeks	4-6 weeks
50 mg	$4,980	4-6 weeks	4-6 weeks
100 mg	$7,968	4-6 weeks	4-6 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	AM-1638 is an orally active GPR40/FFA1 agonist, useful for studying type II diabetes.
Targets&IC50	FFA1/GPR40:0.16 μM
In vivo	Methods: AM-1638 (1 mg/kg, IV) and (5 mg/kg, oral) were administered to mice; AM-1638 (0.5 mg/kg, IV) and (2 mg/kg, oral) were administered to rats; and AM-1638 (0.5 mg/kg, IV) and (2 mg/kg, oral) were administered to cynomolgus monkeys for pharmacokinetic studies. Results: Oral administration of AM-1638 showed excellent oral bioavailability (mice, >100%; rats, 72%; cynomolgus monkeys, 71%); and showed antidiabetic activity in BDF/DIO mice.[1]
Synonyms	AM1638

Chemical Properties

Molecular Weight	514.63
Formula	C₃₃H₃₅FO₄
Cas No.	1142214-62-7
Smiles	FC=1C(C2=C(C=C(COC3=CC([C@@H](CC(O)=O)[C@@H]4CC4)=CC=C3)C=C2)C=5C(C)(C)CCC5)=CC(OC)=CC1
Relative Density.	1.193 g/cm3 (Predicted)

Storage & Solubility Information

Storage

keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (155.45 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (6.41 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9431 mL	9.7157 mL	19.4314 mL	97.1572 mL
5 mM	0.3886 mL	1.9431 mL	3.8863 mL	19.4314 mL
10 mM	0.1943 mL	0.9716 mL	1.9431 mL	9.7157 mL
20 mM	0.0972 mL	0.4858 mL	0.9716 mL	4.8579 mL
50 mM	0.0389 mL	0.1943 mL	0.3886 mL	1.9431 mL
100 mM	0.0194 mL	0.0972 mL	0.1943 mL	0.9716 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc