dp

AH 6809 is an antagonist of EP and DP receptors, with Ki values of 1217, 1150, 1597, and 1415 nM for the cloned human EP1, EP2, EP3-III, and DP receptors, respectively, and a Ki of 350 nM for the mouse EP2 receptor.

AMG-009 is a selective and potent dual antagonist of CRTH2 and DP, with an IC50 value of 3 nM for CRTH2 and 12 nM for DP receptors.

DP-1 hydrochloride is a degradation product of SDC-TRAP-0063, a fragment of Ganetespib, a heat shock protein 90 (HSP90) inhibitor with antitumor activity.

DP-15 acts as a degrader of GSPT1 and BRD4, with DC50 values of 5.25 nM and 0.48 nM, respectively. This compound exhibits antiproliferative activity in AML and NHL cells, showing IC50 values in the nanomolar range, induces G1 phase cell cycle arrest, and triggers apoptosis in MOLM13 cells. Additionally, DP-15 demonstrates anti-leukemic properties in the MOLM-13 xenograft mouse model. [Pink: ligand for target protein JQ-1 carboxylic acid; Black: linker; Blue: ligand for E3 ligaseCereblonThalidomide-5-OH]

PMEG-DP disodium is an effective inhibitor of DNA polymerase (IC50=2.5 μM), exerting strong inhibitory effects particularly on DNA polymerases α and δ. As the active metabolite of GS-9191, it efficiently impedes the growth of cell lines infected with human papillomavirus (HPV). PMEG-DP disodium is useful in research related to HPV-associated diseases.

DP-B 99 (DP-B 99, DP-BAPTA-99, DPB-99, DP-BAPTA-99) is a potential chelating agent for the treatment of acute pancreatitis.

DP-C-4 is a Cereblon-based dual PROTAC for simultaneous degradation of EGFR and PARP[1]. DP-C-4 (1-50 μM; 24 hours) has degradation effects on EGFR and PARP simultaneously in a dose-dependent manner in SW1990 cells[1]. [1]. Mengzhu Zheng, et al. Rational Design and Synthesis of Novel Dual PROTACs for Simultaneous Degradation of EGFR and PARP. J Med Chem. 2021 May 26.

DP-1, a Ganetespib degradation product, represents a fragment derived from SDC-TRAP-0063. Ganetespib itself functions as an inhibitor of heat shock protein 90 (HSP90), exhibiting notable anti-tumor properties.

Dp2mT is an iron chelator which inhibits HIV-1 transcription.

Dp[Tyr(Me)2,Arg8]-Vasopressin is a non-selective antagonist of the peptide arginine vasopressin V1b receptor [1].

Anti-HLA-DP Antibody (B7/21) is an antibody targeting HLA-DP and can be used for life science research.

Fructo-oligosaccharide DP11/GF10 is a fructooligosaccharide (FOS) with a high degree of polymerization of approximately 11. It consists of multiple fructose units linearly linked via β(2→1) glycosidic bonds, with a glucose residue at the terminal end of the molecule. Fructo-oligosaccharide DP11/GF10 belongs to prebiotic substrates and can be selectively utilized by gut microbiota to modulate the structure and metabolic activity of the intestinal flora.

Fructo-oligosaccharide DP12/GF11 is a fructooligosaccharide (FOS) with a high degree of polymerization of 12. It consists of 11 fructose units linearly linked via β(2→1) glycosidic bonds, with a glucose residue at the terminal end of the molecule. It can be selectively fermented by beneficial gut bacteria, thereby influencing the composition and metabolic function of the intestinal microecology.

DP 432 is an insulin hexapeptide fragment.

Fructo-oligosaccharide DP7/GF6 (Fructoheptasaccharide) belongs to fructooligosaccharides (FOS) with degree of polymerization (DP=7).

Dp44mT, a effective iron chelator, has selective antitumor activity.

Fructo-oligosaccharide DP9/GF8 (Fructo-oligosaccharide DP9 / GF8) belongs to fructooligosaccharides (FOS) with the degree of polymerization (DP=9).

Fructo-oligosaccharide DP8/GF7 (Fructo-oligosaccharide DP8 / GF7) is a fructooligosaccharide (FOS) with a degree of polymerization (DP=8). It consists of seven fructose units connected by (2→1)-β-glycosidic bonds, featuring a single D-glucosyl unit at the non-reducing end.

DP00477, a potent inhibitor of indoleamine 2,3-dioxygenase 1 (IDO1), exhibits an inhibitory concentration (IC50) of 7.0 µM. This compound holds promise for cancer research applications.

Fructo-oligosaccharide DP14, an oligosaccharide derived from Atractylodes lancea [1], represents a specific polysaccharide subclass with a degree of polymerization of 14.

Fructo-oligosaccharide DP13 is a high-degree polymerization fructan that belongs to the inulin-type polysaccharides. It can be isolated from Morinda officinalis.

DP32 is a dual-function compound incorporating an opioid receptor (MOP) agonist and a neuropeptide FF receptor (NPFFR) antagonist. It is applicable in analgesia-related research.

DP50 is a bifunctional compound containing both an opioid receptor agonist (MOP) and a neuropeptide FF receptor (NPFFR) antagonist. It can be utilized in studies related to analgesia.

PGD2-IN-1 (PGD2-inhibitor) is an effective DP receptor antagonist (IC50:0.3 nM), a compound that can inhibit prostaglandin D2 (PGD2) signaling. PGD2-IN-1 specifically targets and regulates the activity of PGD2 receptors or enzymes involved IN PGD2 synthesis or metabolism.