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GPCR/G Protein

Cholecystokinin Receptor

Melanin-concentrating Hormone Receptor (MCHR)

(34)

Melanocortin Receptor

Neuropeptide FF Receptor

(15)

Neuropeptide W

(3)

Neuropeptide Y Receptor

Prostaglandin Receptor

(445)

Protease-activated Receptor

Succinate Receptor 1 (SUCNR1)

Neuropeptide FF Receptor

Neuropeptide FF Receptor (NPFFR) constitutes a class of G protein-coupled receptors primarily involved in regulating pain perception and drug addiction. The NPFFR family includes NPFFR1 and NPFFR2, which are widely expressed throughout the central nervous system. Neuropeptide FF activates multiple signalling pathways by binding to NPFFR, thereby regulating pain signal transmission and opioid tolerance. It plays a crucial regulatory role in drug addiction and pain management.

Filter HomeSignaling PathwaysGPCR/G ProteinNeuropeptide FF Receptor

RFRP3(human) acetate(311309-27-0 free base)

TP1936L1

RFRP-3(human) acetate, a human GnIH peptide homolog, is a potent inhibitor of gonadotropin secretion by inhibiting Ca2+ mobilization. RFRP-3(human) acetate is a NPFF1 receptor agonist, it inhibits forskolin-induced production of cAMP with an IC50 of 0.7 n

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Neuropeptide FF acetate(99566-27-5 free base)

TP1074L

Neuropeptide FF acetate(99566-27-5 free base) (NPFF acetate) is an octapeptide belonging to the RF amide family. NPFF interacts with G-protein-coupled receptors NPFF (1) and NPFF (2).

$147

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RF9 acetate

T16738L

RF9 acetate is an effective and selective antagonist of Neuropeptide FF receptor with Ki values of 58 and 75 nM for hNPFF1R and hNPFF2R, respectively.

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AC-263093

T83651849459-86-5

AC-263093 is an NPFFR2 agonist with anxiolytic activity that increases c-Fos protein expression in the paraventricular nucleus of the hypothalamus.

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AC-099 hydrochloride

T83212849335-07-5

AC-099 hydrochloride is a selective full agonist of the neuropeptide FF2 receptor NPFF2R (EC50=1189 nM) and partial agonist function of the neuropeptide FF1 receptor NPFF1R (EC50=2370 nM) that reverses opioid-induced nociceptive sensitization, and may be used to study neurological....

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RFRP-1 (human) acetate(311309-25-8 free base)

TP1937L1

RFRP-1 (human) acetate is a potent endogenous NPFF receptor agonist (EC50 values are 0.0011 and 29 nM for NPFF2 and NPFF1, respectively). Attenuates contractile function of isolated rat and rabbit cardiac myocytes. Reduces heart rate, stroke volume, eject

$133

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Neuropeptide SF(mouse,rat) acetate

TP1884L1

Neuropeptide SF(mouse,rat) acetate (Neuropeptide SF(mouse,rat) acetate (230960-31-3 free base)) is a potent neuropeptide FF receptor agonist, Ki for NPFF1 and NPFF2 are 48.4 nM and 12.1 nM, respectively. Neuropeptide SF(mouse,rat) acetate (Neuropeptide SF(mouse,rat) acetate (230960-31-3 free base)) increases the amplitude of the sustained current of heterologously expressed acid sensing ion channel 3 (ASIC3).

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DP32

TP26812376306-14-6

DP32 is a dual-function compound incorporating an opioid receptor (MOP) agonist and a neuropeptide FF receptor (NPFFR) antagonist. It is applicable in analgesia-related research.

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NPFF1-R antagonist 1

T209569

NPFF1-R antagonist 1 (compound 8b) is a piperidine analog and an effective neuropeptide FF (NPFF) receptor antagonist. It exhibits 15-fold selectivity for the NPFF1-R subtype, with Ki values of 211 nM and 3270 nM for NPFF1-R and NPFF2-R, respectively.

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NPFF2-R ligand 1

T209505

NPFF2-R ligand 1 (Compound 16a) is an NPFF2-R ligand with Ki values of 228 nM for NPFF1-R and 27 nM for NPFF2-R, and can be utilized in research on central nervous system-related disorders.

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GUB03385

TP3547

GUB03385 is a long-acting PrRP31 analogue and an effective dual agonist for GPR10 (full agonist, EC50: 0.4 nM) and NPFF2R (partial agonist, EC50: 20 nM), with anti-obesity properties.

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palm11-PrRP31

TP3581

Palm11-PrRP31 is a lipid-modified analog of the endogenous appetite-suppressing neuropeptide (PrRP). It functions as a potent dual agonist for GPR10 (EC50 = 39 pM) and NPFF-R2. By mimicking the natural activity of PrRP, palm11-PrRP31 binds to these receptors to reduce food intake. It has potential applications as an anti-obesity agent and is useful in studying neuropeptide and receptor interactions.

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palm-PrRP31

TP3585

palm-PrRP31 is a potent dual agonist for GPR10 (EC50=72 pM) and NPFF-R2. It activates downstream signaling pathways by binding to GPR10 and NPFF-R2 receptors, leading to reduced appetite and increased energy expenditure. palm-PrRP31 can be utilized to investigate its mechanism of action in the nervous system, thereby elucidating the complex biological processes involved in the regulation of appetite and energy expenditure.

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Neuropeptide FF

TP107499566-27-5

Endogenous antiopioid peptide and agonist at NPFF1 and NPFF2 receptors (Ki values are 2.82 and 0.21 nM respectively).

$572

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DP50

TP3590

DP50 is a bifunctional compound containing both an opioid receptor agonist (MOP) and a neuropeptide FF receptor (NPFFR) antagonist. It can be utilized in studies related to analgesia.

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