Shopping Cart

Remove All
Your shopping cart is currently empty

Proceed to checkout Continue shopping

GPCR/G Protein

Cholecystokinin Receptor

Melanin-concentrating Hormone Receptor (MCHR)

(34)

Melanocortin Receptor

Neuropeptide FF Receptor

(9)

Neuropeptide W

(3)

Neuropeptide Y Receptor

Prostaglandin Receptor

(434)

Protease-activated Receptor

Succinate Receptor 1 (SUCNR1)

Neuropeptide FF Receptor

Neuropeptide FF Receptor (NPFFR) constitutes a class of G protein-coupled receptors primarily involved in regulating pain perception and drug addiction. The NPFFR family includes NPFFR1 and NPFFR2, which are widely expressed throughout the central nervous system. Neuropeptide FF activates multiple signalling pathways by binding to NPFFR, thereby regulating pain signal transmission and opioid tolerance. It plays a crucial regulatory role in drug addiction and pain management.

Filter HomeSignaling PathwaysGPCR/G ProteinNeuropeptide FF Receptor

RFRP3(human) acetate(311309-27-0 free base)

TP1936L1

RFRP-3(human) acetate, a human GnIH peptide homolog, is a potent inhibitor of gonadotropin secretion by inhibiting Ca2+ mobilization. RFRP-3(human) acetate is a NPFF1 receptor agonist, it inhibits forskolin-induced production of cAMP with an IC50 of 0.7 n

In Stock

Size

QTY

Neuropeptide FF acetate(99566-27-5 free base)

TP1074L

Neuropeptide FF acetate(99566-27-5 free base) (NPFF acetate) is an octapeptide belonging to the RF amide family. NPFF interacts with G-protein-coupled receptors NPFF (1) and NPFF (2).

$147

In Stock

Size

QTY

RF9 acetate

T16738L

RF9 acetate is an effective and selective antagonist of Neuropeptide FF receptor with Ki values of 58 and 75 nM for hNPFF1R and hNPFF2R, respectively.

In Stock

Size

QTY

AC-263093

T83651849459-86-5

AC-263093 is an NPFFR2 agonist with anxiolytic activity that increases c-Fos protein expression in the paraventricular nucleus of the hypothalamus.

In Stock

Size

QTY

AC-099 hydrochloride

T83212849335-07-5

AC-099 hydrochloride is a selective full agonist of the neuropeptide FF2 receptor NPFF2R (EC50=1189 nM) and partial agonist function of the neuropeptide FF1 receptor NPFF1R (EC50=2370 nM) that reverses opioid-induced nociceptive sensitization, and may be used to study neurological....

In Stock

Size

QTY

RFRP-1 (human) acetate(311309-25-8 free base)

TP1937L1

RFRP-1 (human) acetate is a potent endogenous NPFF receptor agonist (EC50 values are 0.0011 and 29 nM for NPFF2 and NPFF1, respectively). Attenuates contractile function of isolated rat and rabbit cardiac myocytes. Reduces heart rate, stroke volume, eject

$133

In Stock

Size

QTY

Neuropeptide SF(mouse,rat) acetate

TP1884L1

Neuropeptide SF(mouse,rat) acetate (Neuropeptide SF(mouse,rat) acetate (230960-31-3 free base)) is a potent neuropeptide FF receptor agonist, Ki for NPFF1 and NPFF2 are 48.4 nM and 12.1 nM, respectively. Neuropeptide SF(mouse,rat) acetate (Neuropeptide SF(mouse,rat) acetate (230960-31-3 free base)) increases the amplitude of the sustained current of heterologously expressed acid sensing ion channel 3 (ASIC3).

In Stock

Size

QTY

DP32

TP26812376306-14-6

DP32 is a dual-function compound incorporating an opioid receptor (MOP) agonist and a neuropeptide FF receptor (NPFFR) antagonist. It is applicable in analgesia-related research.