[D-Phe2,6, Pro3]-LH-RH

Name: [D-Phe2,6, Pro3]-LH-RH
Brand: TargetMol
SKU: T83499
Rating: 4.5 (1 reviews)

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Catalog No. T83499Cas No. 64789-67-9

[D-Phe2,6, Pro3]-LH-RH is a potent antagonist of luteinizing hormone-releasing hormone (LHRH).

[D-Phe2,6, Pro3]-LH-RH

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Catalog No. T83499Cas No. 64789-67-9

[D-Phe2,6, Pro3]-LH-RH is a potent antagonist of luteinizing hormone-releasing hormone (LHRH).

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Product Introduction

Bioactivity

Description	[D-Phe2,6, Pro3]-LH-RH is a potent antagonist of luteinizing hormone-releasing hormone (LHRH).
In vitro	The compound [D-Phe2,6, Pro3]-LH-RH demonstrates agonistic activity by binding to gonadotropin-releasing hormone receptors, which stimulates the secretion of luteinizing hormone and follicle-stimulating hormone, thereby increasing the synthesis of testosterone and estrogen.
In vivo	"[D-Phe2,6, Pro3]-LH-RH (300 mg/monkey, SC, 50 mg/injection; six injections) effectively suppresses spontaneous preovulatory gonadotropin peaks, thereby preventing ovulation in rhesus monkeys [1]. A single dose of [D-Phe2,6, Pro3]-LH-RH (750 μg administered at 12:00 h on proestrus day) achieves 100% inhibition of ovulation in rats [1]."

Chemical Properties

Molecular Weight	1193.35
Formula	C₅₉H₈₀N₁₄O₁₃
Cas No.	64789-67-9
Sequence Short	{Glp}-{d-Phe}-PSY-{d-Phe}-LRPG-NH2

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

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