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TpD

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Catalog No. TP3932Cas No. 1273551-45-3

TpD is a chimeric T-helper epitope that features a specific site for cleavage by caspases. Immunization with TpD induces a strong antibody response and enhances long-term CD4 immune reactions in both animals and humans. It effectively binds to various human MHCII types, primarily HLA-DRB1, and also interacts with other HLA alleles, including DRB3, DRB4, DRB5, DP, and DQ. TpD can be utilized to amplify the immune response in peptide vaccines.

TpD

TpD

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Catalog No. TP3932Cas No. 1273551-45-3
TpD is a chimeric T-helper epitope that features a specific site for cleavage by caspases. Immunization with TpD induces a strong antibody response and enhances long-term CD4 immune reactions in both animals and humans. It effectively binds to various human MHCII types, primarily HLA-DRB1, and also interacts with other HLA alleles, including DRB3, DRB4, DRB5, DP, and DQ. TpD can be utilized to amplify the immune response in peptide vaccines.
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
TpD is a chimeric T-helper epitope that features a specific site for cleavage by caspases. Immunization with TpD induces a strong antibody response and enhances long-term CD4 immune reactions in both animals and humans. It effectively binds to various human MHCII types, primarily HLA-DRB1, and also interacts with other HLA alleles, including DRB3, DRB4, DRB5, DP, and DQ. TpD can be utilized to amplify the immune response in peptide vaccines.
Chemical Properties
Molecular Weight3464.21
FormulaC158H264N38O42S3
Cas No.1273551-45-3
SmilesC([C@@H](NC(CNC([C@@H](NC([C@H](CC1=CC=CC=C1)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC2=CC=C(O)C=C2)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H]([C@H](CC)C)N)=O)CC(C)C)=O)CCSC)=O)CCC(N)=O)=O)=O)[C@H](CC)C)=O)CCCCN)=O)C)=O)CC(N)=O)=O)CO)=O)CCCCN)=O)=O)[C@H](CC)C)=O)=O)[C@H](CC)C)(=O)N3[C@H](C(N[C@H](C(NCC(N[C@H](C(=O)N4[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CCC(N)=O)C(O)=O)=O)C)=O)C(C)C)=O)CCSC)=O)CC(C)C)=O)CO)=O)CO)=O)CC(C)C)=O)C)=O)[C@H](CC)C)=O)CO)=O)CCC(N)=O)=O)CCC4)CC(C)C)=O)=O)CCSC)=O)CCC3
SequenceIle-Leu-Met-Gln-Tyr-Ile-Lys-Ala-Asn-Ser-Lys-Phe-Ile-Gly-Ile-Pro-Met-Gly-Leu-Pro-Gln-Ser-Ile-Ala-Leu-Ser-Ser-Leu-Met-Val-Ala-Gln
Sequence ShortILMQYIKANSKFIGIPMGLPQSIALSSLMVAQ
Storage & Solubility Information
Storagekeep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
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2 Enter the in vivo formulation:
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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