lph

JH-LPH-28, a sulfonyl piperazine analog, is a potent inhibitor of UDP-2,3-diacylglucosamine pyrophosphate hydrolase LpxH, exhibiting exceptional antibiotic activity with a minimum inhibitory concentration (MIC) of 0.83 μg/mL.

JH-LPH-33 is a UDP-2,3-diacylglucosamine pyrophosphate hydrolase LpxH inhibitor with antimicrobial activity for the study of bacterial infections.

LPH-5 is a selective agonist for the 5-HT2A receptor (EC 50 = 190 nM). It functions by specifically activating this receptor, which plays a role in mood regulation, perception, and various central nervous system activities related to the 5-HT2A receptor. LPH-5 may be utilized to investigate the 5-HT2A receptor's involvement in psychiatric conditions such as depression, anxiety, and substance use disorders.

JH-LPH-107, an LpxH inhibitor, exhibits a low spontaneous resistance rate and a high safety margin in vitro.

D-(+)-Glucono-1,5-lactone (Gluconolactone) is a naturally occurring food additive used as a sequestrant, acidifier, curing agent, pickling agent, or leavening agent. It is a cyclic ester of D-gluconic acid and appears as a white, odorless crystalline powder.

p-Ethynylphenylalanine (4-Ethynyl-L-phenylalanine), a selective, effective, and reversible tryptophan hydroxylase (TPH) inhibitor, exhibits competitive inhibition with a Ki of 32.6 μM.

IFN alpha-IFNAR-IN-1 hydrochloride is an inhibitor of the interaction between IFN-α and IFNAR, effectively inhibiting MVA-induced IFN-α responses by BM-pDCs with an IC50 of 2-8 μM.

alphaSYN-IN-NAB2, a neuron-protective agent, is a protein encoded by the NAB2 gene. NAB2 effectively and selectively protects a variety of cells from alpha-SYN toxicity. NAB2 promotes endosomal transport dependent on E3 ubiquitin ligase Rsp5/Nedd4. NAB2 identifies a viable molecular node in alpha-SYN biology that corrects multiple aspects of its underlying pathology, including dysfunctional endosomes and endoplasmic reticulum to Golgi vesicles transport. NAB2 is involved in cellular processes such as cell differentiation, apoptosis and stress response, and can be used to study cancer, neurodevelopment and neuronal activity.

Compound 5936-0108 may has modulationg effect on β-Amyloid.

4-Methylphenylsulfonylurea ,with CAS No. 1694-06-0, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 4-Methylphenylsulfonylurea provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

1,2-O-Isopropylidene-alpha-D-xylofuranose ,with CAS No. 20031-21-4, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 1,2-O-Isopropylidene-alpha-D-xylofuranose provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

1-(2,4-Dimethylphenyl)-2-thiourea ,with CAS No. 16738-20-8, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 1-(2,4-Dimethylphenyl)-2-thiourea provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

(4-Pyrid-4-ylphenyl)methanol ,with CAS No. 217192-22-8, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. (4-Pyrid-4-ylphenyl)methanol provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

2-Methoxy-5-methylphenol ,with CAS No. 1195-09-1, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 2-Methoxy-5-methylphenol provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

(3,4-Dimethylphenyl)methanol ,with CAS No. 6966-10-5, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. (3,4-Dimethylphenyl)methanol provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

3-Trifluoromethylphenol ,with CAS No. 98-17-9, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 3-Trifluoromethylphenol provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

N-(2-methylphenyl)thiourea ,with CAS No. 614-78-8, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. N-(2-methylphenyl)thiourea provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

1-(4-Propylphenyl)ethan-1-one ,with CAS No. 2932-65-2, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 1-(4-Propylphenyl)ethan-1-one provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

N-(3-ethynylphenyl)acetamide ,with CAS No. 70933-58-3, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. N-(3-ethynylphenyl)acetamide provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

4-Fluoro-3-methylphenol ,with CAS No. 452-70-0, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 4-Fluoro-3-methylphenol provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

1-(3-Methylphenyl)-2-thiourea ,with CAS No. 621-40-9, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 1-(3-Methylphenyl)-2-thiourea provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

5-(4-Methylphenyl)-1,3-oxazole ,with CAS No. 143659-19-2, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 5-(4-Methylphenyl)-1,3-oxazole provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

2-Isopropylphenol can undergo catabolism through a broad-spectrum Meta cleavage pathway

2,6-Di-tert-butylphenol ,with CAS No. 128-39-2, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 2,6-Di-tert-butylphenol provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.